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Mulberrofuran Q

CAS# 101383-35-1

Mulberrofuran Q

Catalog No. BCN8844----Order now to get a substantial discount!

Product Name & Size Price Stock
Mulberrofuran Q: 5mg $322 In Stock
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Quality Control of Mulberrofuran Q

Number of papers citing our products

Chemical structure

Mulberrofuran Q

3D structure

Chemical Properties of Mulberrofuran Q

Cas No. 101383-35-1 SDF Download SDF
PubChem ID 5319933 Appearance Powder
Formula C34H24O10 M.Wt 592.55
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(2,4-dihydroxyphenyl)-10,18-dihydroxy-8-(6-hydroxy-1-benzofuran-2-yl)-14-methyl-3,5,15-trioxahexacyclo[12.7.1.02,4.02,12.06,11.016,21]docosa-6,8,10,16(21),17,19-hexaen-13-one
SMILES CC12CC(C3=C(O1)C=C(C=C3)O)C45C(C2=O)C6=C(C=C(C=C6OC4(O5)C7=C(C=C(C=C7)O)O)C8=CC9=C(O8)C=C(C=C9)O)O
Standard InChIKey MSVXRBNAPJJEDX-UHFFFAOYSA-N
Standard InChI InChI=1S/C34H24O10/c1-32-14-22(20-6-4-19(37)13-27(20)42-32)33-30(31(32)40)29-24(39)8-16(25-9-15-2-3-18(36)12-26(15)41-25)10-28(29)43-34(33,44-33)21-7-5-17(35)11-23(21)38/h2-13,22,30,35-39H,14H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mulberrofuran Q

The root bark of Morus alba L.

Biological Activity of Mulberrofuran Q

DescriptionMulberrofuran Q may protect neuronal cell death against the oxidative stress induced by oxygen-glucose deprivation (OGD).
In vitro

Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.[Pubmed: 22297755]

Arch Pharm Res. 2012 Jan;35(1):163-70.


METHODS AND RESULTS:
Seven prenylated flavanoids, licoflavone C (1), cyclomulberrin (2), neocyclomorusin (3), sanggenon I (4), morusin (5), kuwanon U (6) and kuwanon E (7), and three 2-arylbenzofurans, moracin P (8), moracin O (9), and Mulberrofuran Q (10) were isolated from the MeOH extract of Mori Cortex Radicis. Among these, compounds 2-7 enhanced cell viability in a dose-dependent manner against sodium nitroprusside-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay (EC(50) values of 4.4, 5.6, 8.0, 6.4, 8.7, and 11.9 μg/mL, respectively). Among 10 compounds, C-3 prenylated flavones (2, 3, and 5) and prenylated flavanones (4, 6, and 7) showed cell protection. However, compound 1 which lacks the prenyl group at C-3 and three 2-arylbenzofurans (8-10) did not show protective effect. The order of cell protection was as follow: C-3 prenylated flavones (2, 3, and 5) > prenylated flavanones (4, 6, and 7) > 2-arylbenzofurans (8-10) and flavone (1).
CONCLUSIONS:
From this result, we show that some prenylated flavones and flavanones might protect neuronal cells against nitrosative stress-mediated cell death. Even though further evaluations are necessary in vitro and in vivo study, we carefully suggest that some prenylated flavonoids from Mori Cortex Radicis might protect neuronal cells from neurodegenerative diseases.

Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells.[Pubmed: 21910060]

Arch Pharm Res. 2011 Aug;34(8):1373-80.


METHODS AND RESULTS:
Three known 2-arylbenzofurans, moracin P (1), moracin O (2) and Mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC(50) values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC(50) values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner.
CONCLUSIONS:
Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.

Protocol of Mulberrofuran Q

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(3):286-90.

Study on Diels-Alder type adducts from stem barks of Morus yunanensis.[Pubmed: 19445150]

To isolate and identify the Diels-Alder type adducts from stem barks of Morus yunanensis.
METHODS AND RESULTS:
The compounds were isolated and purified by silicagel, Sephadex LH-20 and RP-18 colum chromatography. Their chemical structures were elucidated on the basis ofphysicochemical properties and spectral data. Nine compounds were isolated and identified as: kuwanon G (1), sanggenol M (2), mulberrofuran J (3), guangsangon B (4), resveratrol (5), kuwanon X (6), kuwanon P (7), mulberrofuran O (8), Mulberrofuran Q (9).
CONCLUSIONS:
All the compounds are isolated from the plant for the first time, and compounds 4, 5 have anti-inflammation activities with inhibitory ratios of 57.3%, 50.5% respectively at a concentration of 10 microg mL(-1).

Mulberrofuran Q Dilution Calculator

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Mulberrofuran Q Molarity Calculator

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Preparing Stock Solutions of Mulberrofuran Q

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6876 mL 8.4381 mL 16.8762 mL 33.7524 mL 42.1905 mL
5 mM 0.3375 mL 1.6876 mL 3.3752 mL 6.7505 mL 8.4381 mL
10 mM 0.1688 mL 0.8438 mL 1.6876 mL 3.3752 mL 4.2191 mL
50 mM 0.0338 mL 0.1688 mL 0.3375 mL 0.675 mL 0.8438 mL
100 mM 0.0169 mL 0.0844 mL 0.1688 mL 0.3375 mL 0.4219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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