I2906Antimycobacterial and cytotoxic agent (mycobacterium tuberculosis) CAS# 331963-29-2 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 331963-29-2 | SDF | Download SDF |
| PubChem ID | 54679506 | Appearance | Powder |
| Formula | C25H37N3O4 | M.Wt | 443.58 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | 1-ethyl-4-hydroxy-2-oxo-N'-tridecanoylquinoline-3-carbohydrazide | ||
| SMILES | CCCCCCCCCCCCC(=O)NNC(=O)C1=C(C2=CC=CC=C2N(C1=O)CC)O | ||
| Standard InChIKey | WIEYSVJHCLJOJT-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H37N3O4/c1-3-5-6-7-8-9-10-11-12-13-18-21(29)26-27-24(31)22-23(30)19-16-14-15-17-20(19)28(4-2)25(22)32/h14-17,30H,3-13,18H2,1-2H3,(H,26,29)(H,27,31) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
IC50 Value:
Target: Antibacterial
Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). References: | |||||
I2906 Dilution Calculator
I2906 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2544 mL | 11.2719 mL | 22.5438 mL | 45.0877 mL | 56.3596 mL |
| 5 mM | 0.4509 mL | 2.2544 mL | 4.5088 mL | 9.0175 mL | 11.2719 mL |
| 10 mM | 0.2254 mL | 1.1272 mL | 2.2544 mL | 4.5088 mL | 5.636 mL |
| 50 mM | 0.0451 mL | 0.2254 mL | 0.4509 mL | 0.9018 mL | 1.1272 mL |
| 100 mM | 0.0225 mL | 0.1127 mL | 0.2254 mL | 0.4509 mL | 0.5636 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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I2906 showed antimycobacterial and cytotoxic activity against Mycobacterium tuberculosis and alone or in combination with isoniazid reduced bacterial count in lung and spleen of mouse model of multidrug resistant M. tuberculosis infection.
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In vitro and in vivo activities of a new lead compound I2906 against Mycobacterium tuberculosis.[Pubmed:20530976]
Pharmacology. 2010;85(6):365-71.
BACKGROUND: Due to the long duration of treatment and the emergence of multidrug-resistant strains, new antitubercular agents are urgently needed. I2906, as a novel lead, was screened and tested for efficacy in vitro and in vivo. METHODS: To determine the efficacy of I2906,the minimum inhibitory concentrations against Mycobacterium tuberculosis and cytotoxicity were tested, and its in vivo activities were assessed by administering it to mice infected with M. tuberculosis H37Rv or multidrug-resistant strain. RESULTS: Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). CONCLUSIONS: I2906 displayed potential antimicrobial activities against M. tuberculosis H37Rv and drug-resistant strains in vitro and in vivo, and could improve efficacy of isoniazid in vivo.
