Ibogaine

CAS# 83-74-9

Ibogaine

Catalog No. BCN4378----Order now to get a substantial discount!

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Ibogaine: 5mg $265 In Stock
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Quality Control of Ibogaine

Number of papers citing our products

Chemical structure

Ibogaine

3D structure

Chemical Properties of Ibogaine

Cas No. 83-74-9 SDF Download SDF
PubChem ID 442108 Appearance Powder
Formula C20H26N2O M.Wt 310.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=C(C=C5)OC
Standard InChIKey HSIBGVUMFOSJPD-NXWOVTFFSA-N
Standard InChI InChI=1S/C20H26N2O/c1-3-13-8-12-9-17-19-15(6-7-22(11-12)20(13)17)16-10-14(23-2)4-5-18(16)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13-,17-,20-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ibogaine

The root of Ervatamia hirta

Biological Activity of Ibogaine

Description1. Ibogaine has the propensity to prolong the QT interval of the electrocardiogram in humans, may generate life-threatening cardiac arrhythmias . 2. Ibogaine has promising anti-addictive property in animals.

Ibogaine Dilution Calculator

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Ibogaine Molarity Calculator

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Preparing Stock Solutions of Ibogaine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2216 mL 16.1082 mL 32.2165 mL 64.433 mL 80.5412 mL
5 mM 0.6443 mL 3.2216 mL 6.4433 mL 12.8866 mL 16.1082 mL
10 mM 0.3222 mL 1.6108 mL 3.2216 mL 6.4433 mL 8.0541 mL
50 mM 0.0644 mL 0.3222 mL 0.6443 mL 1.2887 mL 1.6108 mL
100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6443 mL 0.8054 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ibogaine

Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.[Pubmed:22458604]

Addict Biol. 2014 Mar;19(2):237-239.

Ibogaine, an alkaloid derived from the African shrub Tabernanthe iboga, has shown promising anti-addictive properties in animals. Anecdotal evidence suggests that Ibogaine is also anti-addictive in humans. Thus, it alleviates drug craving and impedes relapse of drug use. Although not licensed as therapeutic drug, and despite evidence that Ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine. Here, we report that therapeutic concentrations of Ibogaine reduce currents through human ether-a-go-go-related gene potassium channels. Thereby, we provide a mechanism by which Ibogaine may generate life-threatening cardiac arrhythmias.

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.[Pubmed:23707769]

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):259-68.

The plant alkaloid Ibogaine has promising anti-addictive properties. Albeit not licensed as a therapeutic drug, and despite hints that Ibogaine may perturb the heart rhythm, this alkaloid is used to treat drug addicts. We have recently reported that Ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Thereby the drug may disturb the heart's electrophysiology. Here, to assess the drug's cardiac ion channel profile in more detail, we studied the effects of Ibogaine and its congener 18-Methoxycoronaridine (18-MC) on various cardiac voltage-gated ion channels. We confirmed that heterologously expressed hERG currents are reduced by Ibogaine in low micromolar concentrations. Moreover, at higher concentrations, the drug also reduced human Nav1.5 sodium and Cav1.2 calcium currents. Ion currents were as well reduced by 18-MC, yet with diminished potency. Unexpectedly, although blocking hERG channels, Ibogaine did not prolong the action potential (AP) in guinea pig cardiomyocytes at low micromolar concentrations. Higher concentrations (>/= 10 muM) even shortened the AP. These findings can be explained by the drug's calcium channel inhibition, which counteracts the AP-prolonging effect generated by hERG blockade. Implementation of Ibogaine's inhibitory effects on human ion channels in a computer model of a ventricular cardiomyocyte, on the other hand, suggested that Ibogaine does prolong the AP in the human heart. We conclude that therapeutic concentrations of Ibogaine have the propensity to prolong the QT interval of the electrocardiogram in humans. In some cases this may lead to cardiac arrhythmias.

Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research.[Pubmed:22974549]

Behav Brain Res. 2013 Jan 1;236(1):258-69.

An indole alkaloid, Ibogaine is the principal psychoactive component of the iboga plant, used by indigenous peoples in West Africa for centuries. Modulating multiple neurotransmitter systems, the drug is a potent hallucinogen in humans, although its psychotropic effects remain poorly understood. Expanding the range of model species is an important strategy for translational neuroscience research. Here we exposed adult zebrafish (Danio rerio) to 10 and 20mg/L of Ibogaine, testing them in the novel tank, light-dark box, open field, mirror stimulation, social preference and shoaling tests. In the novel tank test, the zebrafish natural diving response (geotaxis) was reversed by Ibogaine, inducing initial top swimming followed by bottom dwelling. Ibogaine also attenuated the innate preference for dark environments (scototaxis) in the light-dark box test. While it did not exert overt locomotor or thigmotaxic responses in the open field test, the drug altered spatiotemporal exploration of novel environment, inducing clear preference of some areas over others. Ibogaine also promoted 'mirror' exploration in the mirror stimulation test, disrupted group cohesion in the shoaling test, and evoked strong coloration responses due to melanophore aggregation, but did not alter brain c-fos expression or whole-body cortisol levels. Overall, our results support the complex pharmacological profile of Ibogaine and its high sensitivity in zebrafish models, dose-dependently affecting multiple behavioral domains. While future investigations in zebrafish may help elucidate the mechanisms underlying these unique behavioral effects, our study strongly supports the developing utility of aquatic models in hallucinogenic drug research. High sensitivity of three-dimensional phenotyping approaches applied here to behavioral effects of Ibogaine in zebrafish provides further evidence of how 3D reconstructions of zebrafish swimming paths may be useful for high-throughput pharmacological screening.

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