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Isocudraniaxanthone A

CAS# 197447-26-0

Isocudraniaxanthone A

Catalog No. BCN7426----Order now to get a substantial discount!

Product Name & Size Price Stock
Isocudraniaxanthone A: 5mg $886 In Stock
Isocudraniaxanthone A: 10mg Please Inquire In Stock
Isocudraniaxanthone A: 20mg Please Inquire Please Inquire
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Quality Control of Isocudraniaxanthone A

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Chemical structure

Isocudraniaxanthone A

3D structure

Chemical Properties of Isocudraniaxanthone A

Cas No. 197447-26-0 SDF Download SDF
PubChem ID 10687703 Appearance Powder
Formula C18H16O6 M.Wt 328.32
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,3,5,6-tetrahydroxy-4-(2-methylbut-3-en-2-yl)xanthen-9-one
SMILES CC(C)(C=C)C1=C(C=C(C2=C1OC3=C(C2=O)C=CC(=C3O)O)O)O
Standard InChIKey GXZSMOZDSUSQHH-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H16O6/c1-4-18(2,3)13-11(21)7-10(20)12-14(22)8-5-6-9(19)15(23)16(8)24-17(12)13/h4-7,19-21,23H,1H2,2-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isocudraniaxanthone A

The roots of Maclura cochinchinensis.

Biological Activity of Isocudraniaxanthone A

Description1. Isocudraniaxanthone A may have antimalarial activity.
TargetsAntifection

Isocudraniaxanthone A Dilution Calculator

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Isocudraniaxanthone A Molarity Calculator

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Preparing Stock Solutions of Isocudraniaxanthone A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0458 mL 15.229 mL 30.4581 mL 60.9162 mL 76.1452 mL
5 mM 0.6092 mL 3.0458 mL 6.0916 mL 12.1832 mL 15.229 mL
10 mM 0.3046 mL 1.5229 mL 3.0458 mL 6.0916 mL 7.6145 mL
50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2183 mL 1.5229 mL
100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isocudraniaxanthone A

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.[Pubmed:15474559]

Life Sci. 2004 Nov 5;75(25):3077-85.

The antimalarial activity of 22 xanthones against chloroquino-resistant strains of Plasmodium falciparum was evaluated. Natural caloxanthone C (1), demethylcalabaxanthone (2), calothwaitesixanthone (3), calozeyloxanthone (4), dombakinaxanthone (5), macluraxanthone (6), and 6-deoxy-gamma-mangostin (7) were isolated from Calophyllum caledonicum. 1,6-dihydroxyxanthone (8), pancixanthone A (9), isocudraniaxanthone B (10), Isocudraniaxanthone A (11), 2-deprenylrheediaxanthone B (12) and 1,4,5-trihydroxyxanthone (13) were isolated from Garcinia vieillardii. Moreover, synthetic compounds (14-22) are analogues or intermediates of xanthones purified from Calophyllum caledonicum (Oger J.M., Morel C., Helesbeux J.J., Litaudon M., Seraphin D., Dartiguelongue C., Larcher G., Richomme P., Duval O. 2003. First 2-Hydroxy-3-Methylbut-3-Enyl substituted xanthones isolated from Plants: structure elucidation, synthesis and antifungal activity. Natural Product Research 17(3), 195-199; Helesbeux J.J., Duval O., Dartiguelongue C., Seraphin D., Oger J.M., Richomme P., 2004. Synthesis of 2-hydroxy-3-methylbut-3-enyl substituted coumarins and xanthones as natural products. Application of the Schenck ene reaction of singlet oxygen with ortho-prenylphenol precursors. Tetrahedron 60(10), 2293-2300). The relationship between antimalarial activity and molecular structure of xanthones has also been explored. The most potent xanthones (2), (3) and (7) (IC50 = c.a. 1.0 microg/mL) are 1,3,7 trioxygenated and prenylated on the positions 2 and 8.

Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis.[Pubmed:9353889]

Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9.

Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na+/H+ exchange system, erythrinin B (2), euchrenone b10 (3), and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one (4), were isolated from the bark of Erythrina variegata (Fabaceae) (for 2) and the roots of Maclura cochinchinensis (Moraceae) (for 2, 3, 4). Compounds 2, 3, and 4 significantly inhibited the Na+/H+ exchange system of arterial smooth muscle cells, with minimum inhibitory concentrations of 1.25, 1.25, and 10 micrograms/ml, respectively. Three new prenylated xanthones named isocudraniaxanthones B (5) and A (7) and isoalvaxanthone (9) were also isolated from M. cochinchinensis and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.

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