IsopsoralenosideCAS# 905954-18-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 905954-18-9 | SDF | Download SDF |
| PubChem ID | 11574162 | Appearance | Powder |
| Formula | C17H18O9 | M.Wt | 366.3 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (Z)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1-benzofuran-5-yl]prop-2-enoic acid | ||
| SMILES | C1=CC2=C(C=CO2)C(=C1C=CC(=O)O)OC3C(C(C(C(O3)CO)O)O)O | ||
| Standard InChIKey | CAMYXILYLXYDFE-MIVOEOINSA-N | ||
| Standard InChI | InChI=1S/C17H18O9/c18-7-11-13(21)14(22)15(23)17(25-11)26-16-8(2-4-12(19)20)1-3-10-9(16)5-6-24-10/h1-6,11,13-15,17-18,21-23H,7H2,(H,19,20)/b4-2-/t11-,13-,14+,15-,17+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects. |
| Targets | Estrogen receptor | Progestogen receptor |
| In vitro | A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract[Pubmed: 24315982 ]J Ethnopharmacol. 2014;151(1):609-17.The dried fruit of Psoralea corylifolia L. has been used to prevent and treat vitiligo, osteoporosis, arthralgia and asthma in Traditional Chinese Medicine for some 1600 years. |
Isopsoralenoside Dilution Calculator
Isopsoralenoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.73 mL | 13.65 mL | 27.3 mL | 54.6001 mL | 68.2501 mL |
| 5 mM | 0.546 mL | 2.73 mL | 5.46 mL | 10.92 mL | 13.65 mL |
| 10 mM | 0.273 mL | 1.365 mL | 2.73 mL | 5.46 mL | 6.825 mL |
| 50 mM | 0.0546 mL | 0.273 mL | 0.546 mL | 1.092 mL | 1.365 mL |
| 100 mM | 0.0273 mL | 0.1365 mL | 0.273 mL | 0.546 mL | 0.6825 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Psoralenoside
Catalog No.:BCN3196
CAS No.:905954-17-8
- Scutebarbatine B
Catalog No.:BCN4449
CAS No.:905929-95-5
- Tivantinib (ARQ 197)
Catalog No.:BCC3688
CAS No.:905854-02-6
- Sorghumol acetate
Catalog No.:BCN4448
CAS No.:90582-47-1
- Sorghumol
Catalog No.:BCN4447
CAS No.:90582-44-8
- AZ 960
Catalog No.:BCC2197
CAS No.:905586-69-8
- MLN4924
Catalog No.:BCC4057
CAS No.:905579-51-3
- Ethyl 2,4,6-trihydroxybenzoate
Catalog No.:BCN3997
CAS No.:90536-74-6
- 2,5-dihydroxy-3-methoxy-Acetophenone
Catalog No.:BCN3780
CAS No.:90536-47-3
- GDC-0879
Catalog No.:BCC2482
CAS No.:905281-76-7
- TMCB
Catalog No.:BCC7745
CAS No.:905105-89-7
- Cryptochlorogenic acid
Catalog No.:BCN5907
CAS No.:905-99-7
- CGK733
Catalog No.:BCC3911
CAS No.:905973-89-9
- Neochlorogenic acid
Catalog No.:BCN4450
CAS No.:906-33-2
- Teneligliptin hydrobromide
Catalog No.:BCC1992
CAS No.:906093-29-6
- AN-2728
Catalog No.:BCC1361
CAS No.:906673-24-3
- Parvifolixanthone A
Catalog No.:BCN7354
CAS No.:906794-56-7
- Parvifolixanthone B
Catalog No.:BCN7421
CAS No.:906794-57-8
- SCH 546738
Catalog No.:BCC4110
CAS No.:906805-42-3
- Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate
Catalog No.:BCN7597
CAS No.:90685-26-0
- 5-Hydroxysophoranone
Catalog No.:BCN6842
CAS No.:90686-12-7
- Ethyl beta-carboline-1-propionate
Catalog No.:BCN1311
CAS No.:90686-24-1
- (S)-4-Benzyl-2-oxazolidinone
Catalog No.:BCC8401
CAS No.:90719-32-7
- Musellactone
Catalog No.:BCN7183
CAS No.:907583-51-1
A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract.[Pubmed:24315982]
J Ethnopharmacol. 2014;151(1):609-17.
ETHNOPHARMACOLOGICAL RELEVANCE: The dried fruit of Psoralea corylifolia L. has been used to prevent and treat vitiligo, osteoporosis, arthralgia and asthma in Traditional Chinese Medicine for some 1600 years. Psoralen (P), isopsoralen (IP), psoralenoside (PO) and Isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. The first aim of this study is to develop a rapid, sensitive and selective ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) approach for simultaneous determination of PO, IPO, P and IP in rat plasma and samples collected from in vitro incubation experiments. The second aim is to investigate the pharmacokinetic properties of PO, IPO, P and IP after oral administration of Psoralea corylifolia extract (PCE) to rats. The third aim is to confirm the biotransformation of PO to P or IPO to IP under gastrointestinal conditions. MATERIALS AND METHODS: A UPLC-MS/MS method with a C18 column and a mobile phase of methanol-0.1% aqueous formic acid was validated according to the criteria in FDA guidelines about bioanalytical method, which was developed to investigate the pharmacokinetic behavior of PO, IPO, P and IP from PCE and the metabolic pathways of PO to P or IPO to IP. RESULTS: The criteria for establishment of a new UPLC-MS/MS method including selectivity, linearity, accuracy, precision, extraction recovery, matrix effect and stability were validated. This method was successfully applied to the quantitative determination of PO, IPO, P and IP in biological samples collected from both in vitro incubations and in vivo rat experiments. After oral administration of PCE to rat, pharmacokinetic parameters of these four compounds indicated that in vivo biotransformation may occur between PO and P or IPO and IP. Purified benzofuran glycosides fraction (PBGF), containing only PO and IPO, was orally administered to rats to further confirm the biotransformation of PO to P or IPO to IP under gastrointestinal conditions. An in vitro incubation study elucidated that PO and IPO were metabolized to P and IP by intestinal microflora through de-glucosylation. CONCLUSIONS: This paper developed a rapid, sensitive and selective UPLC-MS/MS method for simultaneous determination of PO, IPO, P and IP from PCE in biological samples, and investigated on their comprehensive in vivo and in vitro pharmacokinetic studies. These obtained results showed that the metabolism by intestinal bacteria plays an important role in pharmacological effects of orally administered PCE.
