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Ethyl 2,4,6-trihydroxybenzoate

CAS# 90536-74-6

Ethyl 2,4,6-trihydroxybenzoate

Catalog No. BCN3997----Order now to get a substantial discount!

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Ethyl 2,4,6-trihydroxybenzoate: 5mg $265 In Stock
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Quality Control of Ethyl 2,4,6-trihydroxybenzoate

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Chemical structure

Ethyl 2,4,6-trihydroxybenzoate

3D structure

Chemical Properties of Ethyl 2,4,6-trihydroxybenzoate

Cas No. 90536-74-6 SDF Download SDF
PubChem ID 54344821 Appearance Powder
Formula C9H10O5 M.Wt 198.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name ethyl 2,4,6-trihydroxybenzoate
SMILES CCOC(=O)C1=C(C=C(C=C1O)O)O
Standard InChIKey UBOJATHNUASNAV-UHFFFAOYSA-N
Standard InChI InChI=1S/C9H10O5/c1-2-14-9(13)8-6(11)3-5(10)4-7(8)12/h3-4,10-12H,2H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ethyl 2,4,6-trihydroxybenzoate

The herbs of Celtis biondii

Biological Activity of Ethyl 2,4,6-trihydroxybenzoate

Description1. Ethyl 2,4,6-trihydroxybenzoate suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. 2. Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
TargetsLiver X Receptor

Ethyl 2,4,6-trihydroxybenzoate Dilution Calculator

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Ethyl 2,4,6-trihydroxybenzoate Molarity Calculator

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Preparing Stock Solutions of Ethyl 2,4,6-trihydroxybenzoate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0454 mL 25.227 mL 50.4541 mL 100.9082 mL 126.1352 mL
5 mM 1.0091 mL 5.0454 mL 10.0908 mL 20.1816 mL 25.227 mL
10 mM 0.5045 mL 2.5227 mL 5.0454 mL 10.0908 mL 12.6135 mL
50 mM 0.1009 mL 0.5045 mL 1.0091 mL 2.0182 mL 2.5227 mL
100 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.0091 mL 1.2614 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ethyl 2,4,6-trihydroxybenzoate

Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed:22579484]

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.

The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. Using a reporter gene assay, time-resolved fluorescence resonance energy transfer (TR-FRET), and surface plasmon resonance (SPR) analysis, we showed that ETB directly bound to and stimulated the transcriptional activity of LXR-alpha and LXR-beta. In macrophages, hepatocytes, and intestinal cells, ETB suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-alpha/-beta-responsive genes. Notably, ETB did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes. These results suggest that ETB is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.

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