Ethyl 2,4,6-trihydroxybenzoateCAS# 90536-74-6 |
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| Cas No. | 90536-74-6 | SDF | Download SDF |
| PubChem ID | 54344821 | Appearance | Powder |
| Formula | C9H10O5 | M.Wt | 198.2 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | ethyl 2,4,6-trihydroxybenzoate | ||
| SMILES | CCOC(=O)C1=C(C=C(C=C1O)O)O | ||
| Standard InChIKey | UBOJATHNUASNAV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H10O5/c1-2-14-9(13)8-6(11)3-5(10)4-7(8)12/h3-4,10-12H,2H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Celtis biondii
| Description | 1. Ethyl 2,4,6-trihydroxybenzoate suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. 2. Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. |
| Targets | Liver X Receptor |
Ethyl 2,4,6-trihydroxybenzoate Dilution Calculator
Ethyl 2,4,6-trihydroxybenzoate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.0454 mL | 25.227 mL | 50.4541 mL | 100.9082 mL | 126.1352 mL |
| 5 mM | 1.0091 mL | 5.0454 mL | 10.0908 mL | 20.1816 mL | 25.227 mL |
| 10 mM | 0.5045 mL | 2.5227 mL | 5.0454 mL | 10.0908 mL | 12.6135 mL |
| 50 mM | 0.1009 mL | 0.5045 mL | 1.0091 mL | 2.0182 mL | 2.5227 mL |
| 100 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.0091 mL | 1.2614 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed:22579484]
Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.
The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. Using a reporter gene assay, time-resolved fluorescence resonance energy transfer (TR-FRET), and surface plasmon resonance (SPR) analysis, we showed that ETB directly bound to and stimulated the transcriptional activity of LXR-alpha and LXR-beta. In macrophages, hepatocytes, and intestinal cells, ETB suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-alpha/-beta-responsive genes. Notably, ETB did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes. These results suggest that ETB is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.
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