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Isoshinanolone

CAS# 39626-91-0

Isoshinanolone

Catalog No. BCN7986----Order now to get a substantial discount!

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Quality Control of Isoshinanolone

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Chemical structure

Isoshinanolone

3D structure

Chemical Properties of Isoshinanolone

Cas No. 39626-91-0 SDF Download SDF
PubChem ID 443777 Appearance Powder
Formula C11H12O3 M.Wt 192.21
Type of Compound Quinones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,4R)-4,8-dihydroxy-3-methyl-3,4-dihydro-2H-naphthalen-1-one
SMILES CC1CC(=O)C2=C(C1O)C=CC=C2O
Standard InChIKey YUPNHTWYVBHLMG-KSBSHMNSSA-N
Standard InChI InChI=1S/C11H12O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-4,6,11-12,14H,5H2,1H3/t6-,11-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isoshinanolone

The herbs of Plumbago zeylanica

Biological Activity of Isoshinanolone

Description1. Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL. 2. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells.

Isoshinanolone Dilution Calculator

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Isoshinanolone Molarity Calculator

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Preparing Stock Solutions of Isoshinanolone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2026 mL 26.0132 mL 52.0264 mL 104.0529 mL 130.0661 mL
5 mM 1.0405 mL 5.2026 mL 10.4053 mL 20.8106 mL 26.0132 mL
10 mM 0.5203 mL 2.6013 mL 5.2026 mL 10.4053 mL 13.0066 mL
50 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.0811 mL 2.6013 mL
100 mM 0.052 mL 0.2601 mL 0.5203 mL 1.0405 mL 1.3007 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isoshinanolone

Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.[Pubmed:20347303]

Bioorg Med Chem Lett. 2010 May 1;20(9):2974-7.

A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone. Among the tested compounds, Isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.[Pubmed:28933383]

Diseases. 2016 Jan 15;4(1). pii: diseases4010003.

As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-Isoshinanolone (2) and cis-Isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 muM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 mug/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 mug/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.

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