IsoshinanoloneCAS# 39626-91-0 |
Quality Control & MSDS
3D structure
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| Cas No. | 39626-91-0 | SDF | Download SDF |
| PubChem ID | 443777 | Appearance | Powder |
| Formula | C11H12O3 | M.Wt | 192.21 |
| Type of Compound | Quinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,4R)-4,8-dihydroxy-3-methyl-3,4-dihydro-2H-naphthalen-1-one | ||
| SMILES | CC1CC(=O)C2=C(C1O)C=CC=C2O | ||
| Standard InChIKey | YUPNHTWYVBHLMG-KSBSHMNSSA-N | ||
| Standard InChI | InChI=1S/C11H12O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-4,6,11-12,14H,5H2,1H3/t6-,11-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL. 2. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells. |
Isoshinanolone Dilution Calculator
Isoshinanolone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL | 104.0529 mL | 130.0661 mL |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL | 20.8106 mL | 26.0132 mL |
| 10 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL | 10.4053 mL | 13.0066 mL |
| 50 mM | 0.1041 mL | 0.5203 mL | 1.0405 mL | 2.0811 mL | 2.6013 mL |
| 100 mM | 0.052 mL | 0.2601 mL | 0.5203 mL | 1.0405 mL | 1.3007 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.[Pubmed:20347303]
Bioorg Med Chem Lett. 2010 May 1;20(9):2974-7.
A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone. Among the tested compounds, Isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.
Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.[Pubmed:28933383]
Diseases. 2016 Jan 15;4(1). pii: diseases4010003.
As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-Isoshinanolone (2) and cis-Isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 muM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 mug/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 mug/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.
