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Kaempferol 7-O-rhamnoside

CAS# 20196-89-8

Kaempferol 7-O-rhamnoside

Catalog No. BCN6489----Order now to get a substantial discount!

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Quality Control of Kaempferol 7-O-rhamnoside

Number of papers citing our products

Chemical structure

Kaempferol 7-O-rhamnoside

3D structure

Chemical Properties of Kaempferol 7-O-rhamnoside

Cas No. 20196-89-8 SDF Download SDF
PubChem ID 25079965 Appearance Yellow powder
Formula C21H20O10 M.Wt 432.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
SMILES CC1C(C(C(C(O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O)C4=CC=C(C=C4)O)O)O)O)O
Standard InChIKey HQNOUCSPWAGQND-GKLNBGJFSA-N
Standard InChI InChI=1S/C21H20O10/c1-8-15(24)17(26)19(28)21(29-8)30-11-6-12(23)14-13(7-11)31-20(18(27)16(14)25)9-2-4-10(22)5-3-9/h2-8,15,17,19,21-24,26-28H,1H3/t8-,15-,17+,19+,21-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kaempferol 7-O-rhamnoside

The herbs of Maytenus hookeri

Biological Activity of Kaempferol 7-O-rhamnoside

DescriptionKaempferol 7-O-rhamnoside is a natural product from Maytenus hookeri.
In vitro

Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on α-glucosidase activity.[Pubmed: 28223131]

International Journal of Biological Macromolecules, 2017,98:829-36.

The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their α-glucosidase inhibitory.
METHODS AND RESULTS:
The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), Kaempferol 7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11). The experiments of ultra-filtration combined with liquid chromatography-mass spectrometry (UF-LC-MS) guided quercetin and kaempferol as the key factors for 50% EE showing highly inhibitory activity on α-glucosidase. Quercetin and kaempferol inhibited yeast α-glucosidase in a mixed-type manner with IC50 of 66.8 and 109μg/mL, respectively.
CONCLUSIONS:
These results would provide theoretical underpinning for the C. nitens Oliv. leaves ethanol extracts used as nutraceutical health supplement in the management of type 2 diabetes.

Flavonoids from the leaves of Physalis angulata Linn.[Reference: WebLink]

Planta Med 2013; 79 - PJ5

Plants from the genus Physalis are particularly rich in secondary metabolites. Physalis angulata is a widely distributed annual plant belonging to the nightshade family Solanaceae. Physalis angulata have been used for centuries as medicinal herbs in the treatment of urinary tract infection, skin diseases, gonnorhea, ulcers, sores and as vermicidal drug [1,2].
METHODS AND RESULTS:
The main purpose of this present study is to screen the leaves of this plant for phytochemical constituents that may be responsible for some of these biological activities. The dried leaves of Physalis angulata were sequentially extracted with dichloromethane and 70% methanol. The aqueous methanol extract was partitioned between ethyl acetate and n-butanol. From the n-butanol fraction, four Flavonoids were isolated through column chromatography over silica gel G and sephadex LH-20. Based on the spectroscopic data which include NMR and mass spectroscopy, the chemical structures were determined as quercetin (1), quercetin 3-O-methyl ether (2) isoquercetrin (3) and Kaempferol 7-O-rhamnoside (4).
CONCLUSIONS:
The structures were elucidated using spectroscopic technique and compared with literature [3 – 4]. Anti-oxidant activity using DPPH and anti-bacterial activity of the flavonoids were also investigated. These compounds were isolated for the first time from the leaves of this plant.

Kaempferol 7-O-rhamnoside Dilution Calculator

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Preparing Stock Solutions of Kaempferol 7-O-rhamnoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3127 mL 11.5634 mL 23.1267 mL 46.2535 mL 57.8168 mL
5 mM 0.4625 mL 2.3127 mL 4.6253 mL 9.2507 mL 11.5634 mL
10 mM 0.2313 mL 1.1563 mL 2.3127 mL 4.6253 mL 5.7817 mL
50 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.9251 mL 1.1563 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4625 mL 0.5782 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Kaempferol 7-O-rhamnoside

Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on alpha-glucosidase activity.[Pubmed:28223131]

Int J Biol Macromol. 2017 May;98:829-836.

The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their alpha-glucosidase inhibitory. The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), kaempferol-7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11). The experiments of ultra-filtration combined with liquid chromatography-mass spectrometry (UF-LC-MS) guided quercetin and kaempferol as the key factors for 50% EE showing highly inhibitory activity on alpha-glucosidase. Quercetin and kaempferol inhibited yeast alpha-glucosidase in a mixed-type manner with IC50 of 66.8 and 109mug/mL, respectively. These results would provide theoretical underpinning for the C. nitens Oliv. leaves ethanol extracts used as nutraceutical health supplement in the management of type 2 diabetes.

Description

Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Leaves, is a potent α-glucosidase activity inhibitor. Kaempferol-7-O-rhamnoside has the potential for diabetes.

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