Kushenol S

CAS# 254886-72-1

Kushenol S

Catalog No. BCN8634----Order now to get a substantial discount!

Product Name & Size Price Stock
Kushenol S: 5mg Please Inquire In Stock
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Quality Control of Kushenol S

Number of papers citing our products

Chemical structure

Kushenol S

3D structure

Chemical Properties of Kushenol S

Cas No. 254886-72-1 SDF Download SDF
PubChem ID 10854625 Appearance Powder
Formula C20H20O5 M.Wt 340.37
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
SMILES CC(=CCC1=C(C=C(C2=C1OC(CC2=O)C3=CC=CC=C3O)O)O)C
Standard InChIKey GIFKZTHWWIZJET-SFHVURJKSA-N
Standard InChI InChI=1S/C20H20O5/c1-11(2)7-8-13-15(22)9-16(23)19-17(24)10-18(25-20(13)19)12-5-3-4-6-14(12)21/h3-7,9,18,21-23H,8,10H2,1-2H3/t18-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kushenol S

The roots of Sophora flavescens Ait.

Protocol of Kushenol S

Kinase Assay

A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.[Pubmed: 12161123 ]

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.


METHODS AND RESULTS:
During the search for naturally occurring cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitors, it was found that the extracts from Sophora flavescens exhibit potent inhibitory activity against cGMP PDE5 prepared from rat diaphragm. Therefore, the inhibitory activities of five flavonoids, kushenol H (1), kushenol K (2), kurarinol (3), sophoflavescenol (4) and kuraridine (5), isolated from S. flavescens were measured against cGMP PDE5 to identify potent cGMP PDE5 inhibitory constituents.
CONCLUSIONS:
Among tested compounds, sophoflavescenol (4), a C-8 prenylated flavonol, showed the most potent inhibitory activity (IC(50)=0.013 microM) against cGMP PDE5 with 31.5- and 196.2-fold selectivity over PDE3 and PDE4, respectively. Kinetic analysis revealed that sophoflavescenol was a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM.

Kushenol S Dilution Calculator

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Kushenol S Molarity Calculator

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Preparing Stock Solutions of Kushenol S

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.938 mL 14.6899 mL 29.3798 mL 58.7596 mL 73.4495 mL
5 mM 0.5876 mL 2.938 mL 5.876 mL 11.7519 mL 14.6899 mL
10 mM 0.2938 mL 1.469 mL 2.938 mL 5.876 mL 7.3449 mL
50 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.1752 mL 1.469 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5876 mL 0.7345 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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