Lauterine

CAS# 28200-65-9

Lauterine

Catalog No. BCN7062----Order now to get a substantial discount!

Product Name & Size Price Stock
Lauterine: 5mg $690 In Stock
Lauterine: 10mg Please Inquire In Stock
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Quality Control of Lauterine

Number of papers citing our products

Chemical structure

Lauterine

3D structure

Chemical Properties of Lauterine

Cas No. 28200-65-9 SDF Download SDF
PubChem ID 73104 Appearance Powder
Formula C18H11NO4 M.Wt 305.28
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=CC2=C(C=C1)C(=O)C3=NC=CC4=CC5=C(C2=C43)OCO5
Standard InChIKey BHFUORVSBHCRKK-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H11NO4/c1-21-10-2-3-11-12(7-10)15-14-9(4-5-19-16(14)17(11)20)6-13-18(15)23-8-22-13/h2-7H,8H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lauterine

The plants of Guatteria elata R. E. Fries.

Biological Activity of Lauterine

Description1. Lauterine is a DNA topoisomerase inhibitor.
TargetsTopoisomerase

Lauterine Dilution Calculator

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Lauterine Molarity Calculator

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Preparing Stock Solutions of Lauterine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2757 mL 16.3784 mL 32.7568 mL 65.5136 mL 81.892 mL
5 mM 0.6551 mL 3.2757 mL 6.5514 mL 13.1027 mL 16.3784 mL
10 mM 0.3276 mL 1.6378 mL 3.2757 mL 6.5514 mL 8.1892 mL
50 mM 0.0655 mL 0.3276 mL 0.6551 mL 1.3103 mL 1.6378 mL
100 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.6551 mL 0.8189 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Lauterine

Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.[Pubmed:8158166]

J Nat Prod. 1994 Jan;57(1):68-73.

The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (Lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6. The role of the bioactive oxoaporphine alkaloids as DNA topoisomerase inhibitors is discussed.

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