LauterineCAS# 28200-65-9 |
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| Cas No. | 28200-65-9 | SDF | Download SDF |
| PubChem ID | 73104 | Appearance | Powder |
| Formula | C18H11NO4 | M.Wt | 305.28 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | COC1=CC2=C(C=C1)C(=O)C3=NC=CC4=CC5=C(C2=C43)OCO5 | ||
| Standard InChIKey | BHFUORVSBHCRKK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H11NO4/c1-21-10-2-3-11-12(7-10)15-14-9(4-5-19-16(14)17(11)20)6-13-18(15)23-8-22-13/h2-7H,8H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The plants of Guatteria elata R. E. Fries.
| Description | 1. Lauterine is a DNA topoisomerase inhibitor. |
| Targets | Topoisomerase |
Lauterine Dilution Calculator
Lauterine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2757 mL | 16.3784 mL | 32.7568 mL | 65.5136 mL | 81.892 mL |
| 5 mM | 0.6551 mL | 3.2757 mL | 6.5514 mL | 13.1027 mL | 16.3784 mL |
| 10 mM | 0.3276 mL | 1.6378 mL | 3.2757 mL | 6.5514 mL | 8.1892 mL |
| 50 mM | 0.0655 mL | 0.3276 mL | 0.6551 mL | 1.3103 mL | 1.6378 mL |
| 100 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL | 0.6551 mL | 0.8189 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.[Pubmed:8158166]
J Nat Prod. 1994 Jan;57(1):68-73.
The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (Lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6. The role of the bioactive oxoaporphine alkaloids as DNA topoisomerase inhibitors is discussed.
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