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5-Amino-2-mercaptobenzimidazole

CAS# 2818-66-8

5-Amino-2-mercaptobenzimidazole

Catalog No. BCC8730----Order now to get a substantial discount!

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5-Amino-2-mercaptobenzimidazole: 5mg $17 In Stock
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Chemical structure

5-Amino-2-mercaptobenzimidazole

3D structure

Chemical Properties of 5-Amino-2-mercaptobenzimidazole

Cas No. 2818-66-8 SDF Download SDF
PubChem ID 2734002 Appearance Powder
Formula C7H7N3S M.Wt 165
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-amino-1,3-dihydrobenzimidazole-2-thione
SMILES C1=CC2=C(C=C1N)NC(=S)N2
Standard InChIKey BXDMTLVCACMNJO-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H7N3S/c8-4-1-2-5-6(3-4)10-7(11)9-5/h1-3H,8H2,(H2,9,10,11)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

5-Amino-2-mercaptobenzimidazole Dilution Calculator

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5-Amino-2-mercaptobenzimidazole Molarity Calculator

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Preparing Stock Solutions of 5-Amino-2-mercaptobenzimidazole

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.0606 mL 30.303 mL 60.6061 mL 121.2121 mL 151.5152 mL
5 mM 1.2121 mL 6.0606 mL 12.1212 mL 24.2424 mL 30.303 mL
10 mM 0.6061 mL 3.0303 mL 6.0606 mL 12.1212 mL 15.1515 mL
50 mM 0.1212 mL 0.6061 mL 1.2121 mL 2.4242 mL 3.0303 mL
100 mM 0.0606 mL 0.303 mL 0.6061 mL 1.2121 mL 1.5152 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5-Amino-2-mercaptobenzimidazole

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties.[Pubmed:27834819]

Molecules. 2016 Nov 8;21(11). pii: molecules21111488.

A series of novel pleuromutilin derivatives with substituted benzimidazole moieties were designed and synthesized from pleuromutilin and 5-Amino-2-mercaptobenzimidazole through sequential reactions. All the newly synthesized compounds were characterized by IR, NMR, and HRMS. Each of the derivatives was evaluated in vitro for their antibacterial activity against Escherichia coli (E. coli) and five Gram (+) inoculums. 14-O-((5-amino-benzimidazole-2-yl) thioacetyl) mutilin (3) was the most active compound and showed highest antibacterial activities. Furthermore, we evaluated the inhibition activities of compound 3 on short-term S. aureus and MRSA growth and cytochrome P450 (CYP). The bioassay results indicate that compound 3 could be considered potential antibacterial agents but with intermediate inhibition of CYP3A4.

Experimental and density functional theory study of Raman and SERS spectra of 5-amino-2-mercaptobenzimidazole.[Pubmed:26335062]

Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:344-8.

Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS) and density functional theory (DFT) simulations were employed to study 5-Amino-2-mercaptobenzimidazole (5-A-2MBI) molecules. Ag colloids were used as SERS substrates which were prepared by using hydroxylamine hydrochloride as reducing agent. Raman vibration modes and SERS characteristic peaks of 5-A-2MBI were assigned with the aid of DFT calculations. The molecular electrostatic potential (MEP) of 5-A-2MBI was used to discuss the possible adsorption behavior of 5-A-2MBI on Ag colloids. The spectral analysis showed that 5-A-2MBI molecules were slightly titled via the sulfur atoms adhering to the surfaces of Ag substrates. The obtained SERS spectral intensity decreased when lowering the 5-A-2MBI concentrations. A final detection limit on the concentration of 5x10(-7) mol . L(-1) was gained. SERS proved to be a simple, fast and reliable method for the detection and characterization of 5-A-2MBI molecules.

Design, synthesis, fabrication and in vitro evalution of mucoadhesive 5-amino-2-mercaptobenzimidazole chitosan as low water soluble drug carriers.[Pubmed:25229809]

Eur J Pharm Biopharm. 2014 Nov;88(3):986-97.

Mucoadhesive thiolated chitosan suitable as a carrier for low water soluble drugs was designed and synthesized by conjugating 5-Amino-2-mercaptobenzimidazole (MBI) using methylacrylate (MA) as the linking agent. A 14.4% degree of substitution of MA, as determined by (1)H NMR analysis, and 11.86+/-0.01mumol thiol groups/g of polymer, as determined by Ellman's method, was obtained. The MBI-MA-chitosan had an 11-fold stronger mucoadhesive property compared to unmodified chitosan at pH 1.2, as determined by the periodic acid: Schiff colorimetric method. Chitosan, MA-chitosan and MBI-MA-chitosan were fabricated as well-formed microspheres using electrospray ionization, including an entrapment efficiency of simvastatin (SV) of over 80% for the MBI-MA-chitosan. The mucoadhesiveness of the SV-loaded MBI-MA-CS microspheres was still higher than that for SV-loaded chitosan at pH 1.2 and 6.4. The SV-loaded MBI-MA-CS microspheres revealed a reduced burst effect and an increased release rate (more than fivefold higher than pure SV) of SV over 12h.

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