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Ligustroflavone

CAS# 260413-62-5

Ligustroflavone

Catalog No. BCN2370----Order now to get a substantial discount!

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Quality Control of Ligustroflavone

Number of papers citing our products

Chemical structure

Ligustroflavone

3D structure

Chemical Properties of Ligustroflavone

Cas No. 260413-62-5 SDF Download SDF
PubChem ID 10417462 Appearance White-yellowish powder
Formula C33H40O18 M.Wt 724.67
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Nuezhenoside
Solubility DMSO : 250 mg/mL (344.99 mM; Need ultrasonic)
Chemical Name 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
SMILES CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)OC6C(C(C(C(O6)C)O)O)O)O)O)O)O)O
Standard InChIKey NULBHTHMVOCGOE-ZBCCAYPVSA-N
Standard InChI InChI=1S/C33H40O18/c1-11-22(37)25(40)28(43)31(46-11)45-10-20-24(39)27(42)30(51-32-29(44)26(41)23(38)12(2)47-32)33(50-20)48-15-7-16(35)21-17(36)9-18(49-19(21)8-15)13-3-5-14(34)6-4-13/h3-9,11-12,20,22-35,37-44H,10H2,1-2H3/t11-,12-,20+,22-,23-,24+,25+,26+,27-,28+,29+,30+,31+,32-,33+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ligustroflavone

1 Turpinia sp.

Biological Activity of Ligustroflavone

DescriptionLigustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.
TargetsAMPK | ATP
In vitro

Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]

J Ethnopharmacol. 2000 Jun;70(3):213-7.


METHODS AND RESULTS:
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
CONCLUSIONS:
Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.

Identification of Glycosil Flavones and Determination in vitro of Antioxidant and Photoprotective Activities of Alternanthera brasiliana L. Kuntze.[Reference: WebLink]

Research Journal of Phytochemistry, 2014, 8(4):148-154.

The study Alternanthera brasiliana (L.) Kuntze aims to prove its effectiveness in folk medicine.
METHODS AND RESULTS:
From the study of their chemical constitution were identified by LC-MS technique three glycosylated flavones than were called 2"-O-ramnosylvitexin; 4',5,7-trimethoxy-2"-Oramnosylvitexin and Ligustroflavone. The tests showed high antioxidant capacity of the specie and in small concentrations showed too high levels of photoprotection. In addition its high capacity for photoprotection also paves its use in cosmetology.
CONCLUSIONS:
Alternanthera brasiliana is a species extremely promising with all parameters to become a herbal medicine.

Protocol of Ligustroflavone

Kinase Assay

Assembly of Adiponectin with Ligustroflavone by Activating AMPK.[Reference: WebLink]

Chinese Journal of Experimental Traditional Medical Formulae, 2016(1):18-21.

To investigate activation mechanism of AMPK [adenosine 5'-monophosphate( AMP)-activated protein kinase] by Ligustroflavone,and explore effect of Ligustroflavone on assembly of adiponectin.
METHODS AND RESULTS:
293 T cells were treated with Ligustroflavone. AMPK phosphorylation and evel of cellular AMP and ATP were examined by western blotting and high performance liquid chromatography( HPLC),respectively. 3T3-L1 adipocyte was treated by Ligustroflavone and its effect on assembly of adiponectin was detected. Ligustroflavone can activate AMPK and increase ratio of AMP / ATP in 293 T cells.Ligustroflavone also can promote ssembly of adiponectin multimers.
CONCLUSIONS:
Ligustroflavone activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Structure Identification
Pharmazie. 2000 Jan;55(1):78-80.

Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed: 10683879]

A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.

Ligustroflavone Dilution Calculator

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Ligustroflavone Molarity Calculator

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Preparing Stock Solutions of Ligustroflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3799 mL 6.8997 mL 13.7994 mL 27.5988 mL 34.4985 mL
5 mM 0.276 mL 1.3799 mL 2.7599 mL 5.5198 mL 6.8997 mL
10 mM 0.138 mL 0.69 mL 1.3799 mL 2.7599 mL 3.4498 mL
50 mM 0.0276 mL 0.138 mL 0.276 mL 0.552 mL 0.69 mL
100 mM 0.0138 mL 0.069 mL 0.138 mL 0.276 mL 0.345 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ligustroflavone

Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed:10837985]

J Ethnopharmacol. 2000 Jun;70(3):213-7.

Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system. Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.

Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed:10683879]

Pharmazie. 2000 Jan;55(1):78-80.

A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.

Description

Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice.

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