LochnericineCAS# 72058-36-7 |
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| Cas No. | 72058-36-7 | SDF | Download SDF |
| PubChem ID | 11382599 | Appearance | Powder |
| Formula | C21H24N2O3 | M.Wt | 352.43 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CCC12CC(=C3C4(C1N(CC4)CC5C2O5)C6=CC=CC=C6N3)C(=O)OC | ||
| Standard InChIKey | AUVZFRDLRJQTQF-KXEYLTKFSA-N | ||
| Standard InChI | InChI=1S/C21H24N2O3/c1-3-20-10-12(18(24)25-2)16-21(13-6-4-5-7-14(13)22-16)8-9-23(19(20)21)11-15-17(20)26-15/h4-7,15,17,19,22H,3,8-11H2,1-2H3/t15-,17-,19-,20+,21-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Catharanthus roseus (L.)G.Don
| Description | 1. Lochnericine (LOC) is a component of Voacanga africana, which is a type of traditional medical food in Africa widely used for treating diseases. |
Lochnericine Dilution Calculator
Lochnericine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8374 mL | 14.1872 mL | 28.3744 mL | 56.7489 mL | 70.9361 mL |
| 5 mM | 0.5675 mL | 2.8374 mL | 5.6749 mL | 11.3498 mL | 14.1872 mL |
| 10 mM | 0.2837 mL | 1.4187 mL | 2.8374 mL | 5.6749 mL | 7.0936 mL |
| 50 mM | 0.0567 mL | 0.2837 mL | 0.5675 mL | 1.135 mL | 1.4187 mL |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2837 mL | 0.5675 mL | 0.7094 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Spectroscopy and docking simulations of the interaction between lochnericine and bovine serum albumin.[Pubmed:24942935]
Luminescence. 2015 Mar;30(2):240-6.
Lochnericine (LOC) is a component of Voacanga africana, which is a type of traditional medical food in Africa widely used for treating diseases. In this article, the interaction between LOC and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. Furthermore, Fourier transform infrared (FTIR), Raman and circular dichroism (CD) were used to investigate the structural changes of BSA. The experimental results consistently indicated that LOC changed the secondary structure of BSA. Three structure-similar components were used to study the interference experiments. The molecular modeling results showed that LOC could bind within not only sites I and II, but also bind the cavity of subdomain IB.
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