Home >> Research Area >>Others>>AhR>> 6,2',4'-Trimethoxyflavone

6,2',4'-Trimethoxyflavone

Aryl hydrocarbon receptor antagonist CAS# 720675-74-1

6,2',4'-Trimethoxyflavone

Catalog No. BCC3897----Order now to get a substantial discount!

Product Name & Size Price Stock
6,2',4'-Trimethoxyflavone: 5mg $69 In Stock
6,2',4'-Trimethoxyflavone: 10mg Please Inquire In Stock
6,2',4'-Trimethoxyflavone: 20mg Please Inquire Please Inquire
6,2',4'-Trimethoxyflavone: 50mg Please Inquire Please Inquire
6,2',4'-Trimethoxyflavone: 100mg Please Inquire Please Inquire
6,2',4'-Trimethoxyflavone: 200mg Please Inquire Please Inquire
6,2',4'-Trimethoxyflavone: 500mg Please Inquire Please Inquire
6,2',4'-Trimethoxyflavone: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of 6,2',4'-Trimethoxyflavone

Number of papers citing our products

Chemical structure

6,2',4'-Trimethoxyflavone

3D structure

Chemical Properties of 6,2',4'-Trimethoxyflavone

Cas No. 720675-74-1 SDF Download SDF
PubChem ID 688802 Appearance Powder
Formula C18H16O5 M.Wt 312.32
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 5 mM in DMSO with gentle warming
Chemical Name 2-(2,4-dimethoxyphenyl)-6-methoxychromen-4-one
SMILES COC1=CC2=C(C=C1)OC(=CC2=O)C3=C(C=C(C=C3)OC)OC
Standard InChIKey WUWFDVDASNSUKP-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H16O5/c1-20-11-5-7-16-14(8-11)15(19)10-18(23-16)13-6-4-12(21-2)9-17(13)22-3/h4-10H,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of 6,2',4'-Trimethoxyflavone

DescriptionAryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). Exhibits no short term agonist activity and no species or promoter dependence.

6,2',4'-Trimethoxyflavone Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

6,2',4'-Trimethoxyflavone Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 6,2',4'-Trimethoxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2018 mL 16.0092 mL 32.0184 mL 64.0369 mL 80.0461 mL
5 mM 0.6404 mL 3.2018 mL 6.4037 mL 12.8074 mL 16.0092 mL
10 mM 0.3202 mL 1.6009 mL 3.2018 mL 6.4037 mL 8.0046 mL
50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2807 mL 1.6009 mL
100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on 6,2',4'-Trimethoxyflavone

Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). Exhibits no short term agonist activity and no species or promoter dependence.

Featured Products
New Products
 

References on 6,2',4'-Trimethoxyflavone

Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.[Pubmed:19828881]

J Pharmacol Exp Ther. 2010 Jan;332(1):135-44.

The aryl hydrocarbon receptor (AHR) is regarded as an important homeostatic transcriptional regulator within physiological and pathophysiological processes, including xenobiotic metabolism, endocrine function, immunity, and cancer. Agonist activation of the AHR is considered deleterious based on toxicological evidence obtained with environmental pollutants, which mediate toxic effects through AHR. However, a multitude of plant-derived constituents, e.g., polyphenols that exhibit beneficial properties, have also been described as ligands for the AHR. It is conceivable that some of the positive aspects of such compounds can be attributed to suppression of AHR activity through antagonism. Therefore, we conducted a dioxin response element reporter-based screen to assess the AHR activity associated with a range of flavonoid compounds. Our screen identified two flavonoids (5-methoxyflavone and 7,4'-dimethoxyisoflavone) with previously unidentified AHR agonist potential. In addition, we have identified and characterized 6,2',4'-trimethoxyflavone (TMF) as an AHR ligand that possesses the characteristics of an antagonist having the capacity to compete with agonists, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo[a]pyrene, thus effectively inhibiting AHR-mediated transactivation of a heterologous reporter and endogenous targets, e.g., CYP1A1, independent of cell lineage or species. Furthermore, TMF displays superior action by virtue of having no partial agonist activity, in contrast to other documented antagonists, e.g., alpha-napthoflavone, which are partial weak agonists. TMF also exhibits no species or promoter dependence with regard to AHR antagonism. TMF therefore represents an improved tool allowing for more precise dissection of AHR function in the absence of any conflicting agonist activity.

Keywords:

6,2',4'-Trimethoxyflavone,720675-74-1,Natural Products,AhR, buy 6,2',4'-Trimethoxyflavone , 6,2',4'-Trimethoxyflavone supplier , purchase 6,2',4'-Trimethoxyflavone , 6,2',4'-Trimethoxyflavone cost , 6,2',4'-Trimethoxyflavone manufacturer , order 6,2',4'-Trimethoxyflavone , high purity 6,2',4'-Trimethoxyflavone

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: