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2-Hydroxyeupatolide

CAS# 72229-33-5

2-Hydroxyeupatolide

Catalog No. BCN2490----Order now to get a substantial discount!

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Quality Control of 2-Hydroxyeupatolide

Number of papers citing our products

Chemical structure

2-Hydroxyeupatolide

3D structure

Chemical Properties of 2-Hydroxyeupatolide

Cas No. 72229-33-5 SDF Download SDF
PubChem ID 71317258 Appearance Cryst.
Formula C15H20O4 M.Wt 264.32
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3aR,4R,6Z,8S,10Z)-4,8-dihydroxy-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
SMILES CC1=CC2C(C(CC(=CC(C1)O)C)O)C(=C)C(=O)O2
Standard InChIKey FGJATCOCAOQTBA-CKXNSKPFSA-N
Standard InChI InChI=1S/C15H20O4/c1-8-4-11(16)5-9(2)7-13-14(12(17)6-8)10(3)15(18)19-13/h4,7,11-14,16-17H,3,5-6H2,1-2H3/b8-4-,9-7-/t11-,12-,13?,14-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2-Hydroxyeupatolide

The herbs of Eupatorium lindleyanum

Biological Activity of 2-Hydroxyeupatolide

Description2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants.
TargetsNF-κB | NO | TNF-α | p65 | IL Recepter

Protocol of 2-Hydroxyeupatolide

Kinase Assay

2-Hydroxyeupatolide attenuates inflammatory responses via the inhibiting of NF-κB signaling pathways.[Reference: WebLink]

RSC Advances,2017,7(60):37830-37838.

2-Hydroxyeupatolide (2-HE), a sesquiterpene lactone, was found in the genus Eupatorium that has been used for a long time in traditional Chinese medicine for the treatment of several diseases.
METHODS AND RESULTS:
In this study, the anti-inflammatory activity of 2-HE and the underlying mechanism of this action were explored. We demonstrated that 2-HE ameliorated hyperemia, edema, alveolar wall thickening, and inflammatory cell infiltration in the lung tissues, and inhibited the serum inflammatory cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) of lipopolysaccharide (LPS) challenged ICR mice effectively. Besides, 2-HE inhibited the mRNA expression levels of IL-6 in lung, spleen, and hypothalamus in the mice. Moreover, 2-HE was found to suppress the production of nitric oxide (NO) and the mRNA and protein levels of TNF-α, IL-1β, and IL-6 in LPS-treated RAW 264.7 macrophage cells in a concentration-dependent manner. The mechanistic study showed that 2-HE inhibited the nuclear factor-kappa B (NF-κB) transactivity and nucleic translocation of NF-κB p65 and p-NF-κB p65 in RAW 264.7 cells.
CONCLUSIONS:
Taken together, our study suggested that 2-HE may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants.

2-Hydroxyeupatolide Dilution Calculator

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2-Hydroxyeupatolide Molarity Calculator

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Preparing Stock Solutions of 2-Hydroxyeupatolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7833 mL 18.9165 mL 37.8329 mL 75.6659 mL 94.5823 mL
5 mM 0.7567 mL 3.7833 mL 7.5666 mL 15.1332 mL 18.9165 mL
10 mM 0.3783 mL 1.8916 mL 3.7833 mL 7.5666 mL 9.4582 mL
50 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.5133 mL 1.8916 mL
100 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.7567 mL 0.9458 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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