Malvidin-3-O-glucoside chloride

1 Erica sp. 2 Malva sp. 3 Phaseolus sp. 4 Primula sp. 5 Rhododendron sp. 6 Vaccinium sp. 7 Vitis sp.

Malvidin 3-O-β-glucopyranoside is a natural colorant found in bilberries and other fruits and flowers. It is produced from natural sources (extraction processes). The product will release hydrochloric acid in water. The product is hygroscopic.The chemical formula is C23H25O12Cl. The molecular weight is 528.9 g/mol. The product belongs to the anthocyanins, which is a class of natural chemicals belonging to the flavonoids. It is highly water-soluble and is easily degraded by hydrolysis and /or hydrogenation at temperatures >40°C.The product shall be dark red /purple in colour, and shall normally be powdered.The product has a purity >98% as detected by high- performance liquid chromatography (HPLC) connected to UV /Vis detector at 280nm and 520nm. The rest is impurities of other anthocyanins, flavonoids or polyphenols.The product should be kept in darkness and at low temperatures for storage more than a few days (< -5°C).

Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions.[Pubmed:19924259]

J Food Biochem. 2008 Sep 23;32(5):576-596.

Anthocyanins and their aglycone anthocyanidins are pigmented flavonoids found in significant amounts in many commonly consumed foods. They exhibit a complex chemistry in aqueous solution, which makes it difficult to study their chemistry under physiological conditions. Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study-cyanidin chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, malvidin 3-O-glucoside and luteolinidin chloride. The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds. However, we observed that all of the anthocyan(id)ins used in this study were capable of inducing significant oxidative DNA strand cleavage (nicking) in the presence of 1 mM DTT (dithiothreitol), while the free radical scavenger, DMSO, at concentrations typically used in similar studies, completely inhibited DNA nicking. Finally, we propose a mechanism to explain the anthocyan(id)in induced oxidative DNA cleavage observed under our experimental conditions.

Malvidin-3-O-glucoside chloride,7228-78-6,Oenin chloride,Natural Products, buy Malvidin-3-O-glucoside chloride , Malvidin-3-O-glucoside chloride supplier , purchase Malvidin-3-O-glucoside chloride , Malvidin-3-O-glucoside chloride cost , Malvidin-3-O-glucoside chloride manufacturer , order Malvidin-3-O-glucoside chloride , high purity Malvidin-3-O-glucoside chloride