Oxacillin sodium monohydrateCAS# 7240-38-2 |
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Quality Control & MSDS
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| Cas No. | 7240-38-2 | SDF | Download SDF |
| PubChem ID | 23694213 | Appearance | Powder |
| Formula | C19H20N3NaO6S | M.Wt | 441.43 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Sodium oxacillin monohydrate | ||
| Solubility | H2O : ≥ 100 mg/mL (226.54 mM) DMSO : 50 mg/mL (113.27 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | sodium;(2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate | ||
| SMILES | CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+] | ||
| Standard InChIKey | ZVIYWUUZWWBNMB-VICXVTCVSA-M | ||
| Standard InChI | InChI=1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Oxacillin sodium monohydrate is an antibiotic similar to flucloxacillin used in resistant staphylococci infections.
Target: Antibacterial
Oxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Another related compound is nafcillin. Since it is resistant to penicillinase enzymes, such as that produced by Staphylococcus aureus, it is widely used clinically in the US to treat penicillin-resistant Staphylococcus aureus. However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (MRSA/ORSA) have become increasingly prevalent worldwide. MRSA/ORSA is treated using vancomycin. From Wikipedia. References: | |||||
Oxacillin sodium monohydrate Dilution Calculator
Oxacillin sodium monohydrate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2654 mL | 11.3268 mL | 22.6536 mL | 45.3073 mL | 56.6341 mL |
| 5 mM | 0.4531 mL | 2.2654 mL | 4.5307 mL | 9.0615 mL | 11.3268 mL |
| 10 mM | 0.2265 mL | 1.1327 mL | 2.2654 mL | 4.5307 mL | 5.6634 mL |
| 50 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 0.9061 mL | 1.1327 mL |
| 100 mM | 0.0227 mL | 0.1133 mL | 0.2265 mL | 0.4531 mL | 0.5663 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Oxacillin sodium monohydrate
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Tissue distribution of oxacillin and ampicillin in the isolated perfused bovine udder.[Pubmed:10842465]
J Vet Med A Physiol Pathol Clin Med. 2000 Apr;47(3):157-68.
In vivo, tissue distribution of intra-mammarily administered antibiotics is mostly only assessed by sampling milk and blood. Therefore, the described study analysed whether measurement of tissue concentrations makes sense in vitro instead. Isolated bovine udders were perfused with gassed and warmed Tyrode solution. To four front and rear quarters each, 1000 mg oxacillin in 7.5 ml vehicle was administered intracisternally, completely formulated as sodium monohydrate in two lactation ointments (with or without sodium dodecylsulphate) or 80% as benzathine salt in a dry-off ointment. Over 3 h, perfusate and glandular tissue from different locations were sampled and analysed by high pressure liquid chromatography. With increasing vertical distance to the teat base, the tissue concentration of antibiotics decreased. With the lactation ointment containing sodium dodecylsulphate, lower oxacillin concentrations were reached in glandular tissue and lymph nodes compared to those without. The ointments led to a higher recovery of oxacillin in glandular tissue than in perfusate. Aluminium monostearate in the dry-off ointment caused an even poorer absorption of oxacillin into perfusate. The isolated perfused bovine udder is suitable to study the tissue distribution of antibiotics, since the results were mainly comparable with the few existing in vivo studies and show the influence of different formulations.
Oxacillin sodium monohydrate is an antibiotic similar to flucloxacillin used in resistant staphylococci infections.
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