11-HydroxytephrosinCAS# 72458-85-6 |
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| Cas No. | 72458-85-6 | SDF | Download SDF |
| PubChem ID | 155725 | Appearance | Yellow powder |
| Formula | C23H22O8 | M.Wt | 426.4 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1(C=CC2=C3C(=C(C=C2O1)O)C(=O)C4(C(O3)COC5=CC(=C(C=C54)OC)OC)O)C | ||
| Standard InChIKey | OFLCPNIRDVOOEZ-WZONZLPQSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Derris robusta
| Description | 1. 11-Hydroxytephrosin inhibits NF-kappaB activity. |
| Targets | NF-kB | TNF-α |
11-Hydroxytephrosin Dilution Calculator
11-Hydroxytephrosin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3452 mL | 11.7261 mL | 23.4522 mL | 46.9043 mL | 58.6304 mL |
| 5 mM | 0.469 mL | 2.3452 mL | 4.6904 mL | 9.3809 mL | 11.7261 mL |
| 10 mM | 0.2345 mL | 1.1726 mL | 2.3452 mL | 4.6904 mL | 5.863 mL |
| 50 mM | 0.0469 mL | 0.2345 mL | 0.469 mL | 0.9381 mL | 1.1726 mL |
| 100 mM | 0.0235 mL | 0.1173 mL | 0.2345 mL | 0.469 mL | 0.5863 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.[Pubmed:18841906]
J Nat Prod. 2008 Oct;71(10):1696-700.
NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new compounds, 5, 7, 8, and 9, and eight known compounds. Their structures were elucidated by spectroscopic methods. All compounds inhibited NF-kappaB activity, and tephrosin (1), 11-Hydroxytephrosin (2), and deguelin (3) were the most active, with IC50 values of 0.11, 0.19, and 0.22 microM, respectively, in TNF-alpha-stimulated HeLa cell-based reporter gene assays. Further investigations showed that compounds 1, 5, and 6 blocked NF-kappaB/DNA binding activity and suppressed the expression of NF-kappaB target genes.
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