Lupinalbin ACAS# 98094-87-2 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 98094-87-2 | SDF | Download SDF |
| PubChem ID | 5324349 | Appearance | Powder |
| Formula | C15H8O6 | M.Wt | 284.03 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,3,8-trihydroxy-[1]benzofuro[2,3-b]chromen-11-one | ||
| SMILES | C1=CC2=C(C=C1O)OC3=C2C(=O)C4=C(C=C(C=C4O3)O)O | ||
| Standard InChIKey | BBBAWACESCACAP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H8O6/c16-6-1-2-8-10(4-6)20-15-12(8)14(19)13-9(18)3-7(17)5-11(13)21-15/h1-5,16-18H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation. 2. Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). |
| Targets | STAT | IFN-γ | IL Receptor | Estrogen receptor | Progestogen receptor |
Lupinalbin A Dilution Calculator
Lupinalbin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5208 mL | 17.6038 mL | 35.2075 mL | 70.4151 mL | 88.0189 mL |
| 5 mM | 0.7042 mL | 3.5208 mL | 7.0415 mL | 14.083 mL | 17.6038 mL |
| 10 mM | 0.3521 mL | 1.7604 mL | 3.5208 mL | 7.0415 mL | 8.8019 mL |
| 50 mM | 0.0704 mL | 0.3521 mL | 0.7042 mL | 1.4083 mL | 1.7604 mL |
| 100 mM | 0.0352 mL | 0.176 mL | 0.3521 mL | 0.7042 mL | 0.8802 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-Inflammatory Effect of Lupinalbin A Isolated from Apios americana on Lipopolysaccharide-Treated RAW264.7 Cells.[Pubmed:29509670]
Molecules. 2018 Mar 6;23(3). pii: molecules23030583.
Apios americana, a leguminous plant, is used as food in some countries. Although the biological activities of Apios extract have been reported, there have been no reports about the anti-inflammatory mechanism of Lupinalbin A on the RAW264.7 cells. In this study, we investigated the anti-inflammatory effect of A. americana Lupinalbin A on lipopolysaccharide (LPS)-treated RAW264.7 cells. Lupinalbin A significantly inhibited nitric oxide production and inducible nitric oxide synthase expression in LPS-treated RAW264.7 cells. The expression of cytokines, including interleukin-6, tumor necrosis factor-alpha, and chemokine of monocyte chemoattractant protein, was reduced under Lupinalbin A exposure in LPS-treated RAW264.7 cells. In addition, Lupinalbin A significantly decreased LPS-induced interferon (IFN)-beta production and STAT1 protein levels in RAW264.7 cells. Taken together, these results suggest that A. americana Lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-beta/STAT1 pathway activation.
Lupinalbin A as the most potent estrogen receptor alpha- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae).[Pubmed:25106881]
BMC Complement Altern Med. 2014 Aug 9;14:294.
BACKGROUND: Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to exhibit estrogenic and aryl hydrocarbon receptor agonistic activities in vitro and to prevent menopausal symptoms in ovariectomized Wistar rats. METHODS: In order to determine the major estrogen receptor alpha (ERalpha) agonists in the extract, an activity-guided fractionation was performed using the ERalpha yeast screen. To check whether the ERalpha active fractions/compounds also accounted for the aryl hydrocarbon receptor (AhR) agonistic activity of the crude methanol extract, they were further tested on the AhR yeast screen. RESULTS: This study led to the identification of 2'-hydroxygenistein, Lupinalbin A and genistein as major estrogenic principles of the extract. 2'-hydroxygenistein and Lupinalbin A were, for the first time, also shown to possess an AhR agonistic activity, whereas genistein was not active in this assay. In addition, it was possible to deduce structure-activity relationships. CONCLUSIONS: These results suggest that the identified compounds are the major active principles responsible for the estrogenic and AhR agonistic activities of the crude methanol extract of the aerial parts of Eriosema laurentii.
