Difloxacin HClquinolone antimicrobial antibiotic CAS# 98106-17-3 |
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Quality Control & MSDS
3D structure
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| Cas No. | 98106-17-3 | SDF | Download SDF |
| PubChem ID | 56206 | Appearance | Powder |
| Formula | C21H19F2N3O3 HCl | M.Wt | 435.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | ||
| SMILES | CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F | ||
| Standard InChIKey | NOCJXYPHIIZEHN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Difloxacin HCl Dilution Calculator
Difloxacin HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2943 mL | 11.4716 mL | 22.9431 mL | 45.8863 mL | 57.3579 mL |
| 5 mM | 0.4589 mL | 2.2943 mL | 4.5886 mL | 9.1773 mL | 11.4716 mL |
| 10 mM | 0.2294 mL | 1.1472 mL | 2.2943 mL | 4.5886 mL | 5.7358 mL |
| 50 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 0.9177 mL | 1.1472 mL |
| 100 mM | 0.0229 mL | 0.1147 mL | 0.2294 mL | 0.4589 mL | 0.5736 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Difloxacin HCl is a quinolone antimicrobial antibiotic [1].
Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.
In unselected cultured human neuroblastoma cells, difloxacin (50 microg/ml) increased sensitivity to the multidrug resistance-associated protein (MRP) substrates. Daunorubicin, doxorubicin, vincristine and potassium antimony tartrate is proportional to the level of MRP expression, which proves that difloxacin HCl reverse drug resistance in human neuroblastoma cells [1].
Difloxacin HCl is a quinolone antimicrobial antibiotic and may reverse drug resistance in human neuroblastoma cells. Difloxacin HCl is commonly used in clinical in vitro antimicrobial susceptibility tests against gram-positive and gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.
References:
[1]. Norris MD, Madafiglio J, Gilbert J, et al. Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin. Med Pediatr Oncol, 2001, 36(1): 177-180.
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