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Sarafloxacin HCl

CAS# 91296-87-6

Sarafloxacin HCl

Catalog No. BCC4713----Order now to get a substantial discount!

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Chemical structure

Sarafloxacin HCl

3D structure

Chemical Properties of Sarafloxacin HCl

Cas No. 91296-87-6 SDF Download SDF
PubChem ID 56207 Appearance Powder
Formula C20H18ClF2N3O3 M.Wt 421.83
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 8.33 mg/mL (19.75 mM; Need ultrasonic)
H2O : 1 mg/mL (2.37 mM; ultrasonic and warming and heat to 60°C)
Chemical Name 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
SMILES [H+].[Cl-].OC(=O)C1=CN(c2ccc(F)cc2)c3cc(N4CCNCC4)c(F)cc3C1=O
Standard InChIKey KNWODGJQLCISLC-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Sarafloxacin HCl Dilution Calculator

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Sarafloxacin HCl Molarity Calculator

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Preparing Stock Solutions of Sarafloxacin HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3706 mL 11.8531 mL 23.7062 mL 47.4125 mL 59.2656 mL
5 mM 0.4741 mL 2.3706 mL 4.7412 mL 9.4825 mL 11.8531 mL
10 mM 0.2371 mL 1.1853 mL 2.3706 mL 4.7412 mL 5.9266 mL
50 mM 0.0474 mL 0.2371 mL 0.4741 mL 0.9482 mL 1.1853 mL
100 mM 0.0237 mL 0.1185 mL 0.2371 mL 0.4741 mL 0.5927 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Sarafloxacin HCl

Sarafloxacin hydrochloride is a quinolone antibiotic drug.

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References on Sarafloxacin HCl

Determination of fluoroquinolone residues in poultry muscle in Portugal.[Pubmed:20496028]

Anal Bioanal Chem. 2010 Jul;397(6):2615-21.

A total of 98 poultry samples, including chicken and turkey muscle, were analysed, using a sensitive and reliable analytical method based on liquid chromatography (LC) with spectrofluorimetric detection, for simultaneous determination of four fluoroquinolone (FQ) antibiotics, namely enrofloxacin (ENRO), ciprofloxacin (CIPRO), norfloxacin (NOR), and sarafloxacin (SARA). The method involved extraction with 0.15 mol L(-1) HCl and clean-up by solid-phase extraction using Oasis HLB cartridges. Chromatographic separation was carried out on a C(18) TSK gel column, in isocratic mode, with 0.025 mol L(-1) H(3)PO(4) solution, adjusted to pH 3.0 with tetrabutylammonium hydroxide-methanol (78:22) as mobile phase. Good linearity over the investigated concentration range was observed, with mean values of correlation coefficients higher than 0.9989 for all the analytes studied. The limits of quantification (LOQ), expressed as the lowest fortification level with acceptable precision were 15 microg kg(-1) for ENRO, CIPRO, and NOR, and 30 microg kg(-1) for SARA; these values are in compliance with requirements for monitoring of maximum residues levels (MRLs). Overall recoveries from spiked samples ranged from 80% to 92% with relative standard deviations (RSD) lower than 6.1%. Of the chicken and turkey samples analysed, 44.2% and 37.8%, respectively, were contaminated. The levels found in the analysed poultry samples, collected from markets of Oporto and Coimbra, located in the north and central zones of Portugal, respectively, were lower than 114.2 and 87.6 microg kg(-1) in chicken and turkey muscle samples, respectively. One positive chicken sample was contaminated with ENRO at levels higher than the MRL.

In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea.[Pubmed:2327784]

Antimicrob Agents Chemother. 1990 Feb;34(2):368-70.

Tosufloxacin (A-60969 HCl), a new quinolone with broad activity against gram-positive and anaerobic organisms, was compared in vitro with other quinolones against bacterial pathogens of diarrhea. Tosufloxacin was the most active agent against Salmonella spp., Shigella spp., Campylobacter spp., Aeromonas hydrophila, and Vibrio spp. Temafloxacin (A-62254) also demonstrated good activity against these organisms.

Heat-induced formulation inhomogeneity of a three-component suspension.[Pubmed:15491051]

Drug Dev Ind Pharm. 2004 Aug;30(7):731-7.

A suspension formulation containing Sarafloxacin HCl, triamcinolone acetonide, and clotrimazole was developed for the treatment of otitis externa in dogs. The potency for the three active ingredients in this suspension was monitored at 25 degrees C and 40 degrees C for up to 3 months. The potencies of triamcinolone and clotrimazole were found unchanged, but the potency of Sarafloxacin HCl in the samples stored at 40 degrees C for 1 month varied significantly between samples. However, assay inconsistency for Sarafloxacin HCl was not seen in samples stored at 25 degrees C. Under an optical microscope, large crystals were found in the 40 degrees C stability samples but not in the 25 degrees C samples. The large crystals in 40 degrees C samples were identified as sarafloxacin by high-performance liquid chromatography (HPLC). This finding suggests that crystal growth of sarafloxacin took place at 40 degrees C during storage, leading to the formation of larger crystals and the consequent sampling nonuniformity and assay inconsistency. The solid-state properties of these crystals were further evaluated using hot-stage microscopy and Fourier transform infrared (FTIR) analysis. The results indicate that the crystal growth of sarafloxacin was most likely attributed to a change in the hydration form of sarafloxacin.

Description

Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic drug.

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