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Ophiopogonin C

CAS# 911819-08-4

Ophiopogonin C

2D Structure

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Quality Control of Ophiopogonin C

3D structure

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Ophiopogonin C

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Chemical Properties of Ophiopogonin C

Cas No. 911819-08-4 SDF Download SDF
PubChem ID 90477999 Appearance Powder
Formula C46H72O17 M.Wt 897.06
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)OC(=O)C)OC7C(C(C(C(O7)C)O)OC8C(C(C(CO8)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1
Standard InChIKey MQTJXIHSKXORQL-RFMZWHELSA-N
Standard InChI InChI=1S/C46H72O17/c1-19-10-13-46(56-17-19)20(2)32-30(63-46)16-28-26-9-8-24-14-25(59-23(5)47)15-31(45(24,7)27(26)11-12-44(28,32)6)60-43-40(62-42-38(54)36(52)33(49)21(3)57-42)39(34(50)22(4)58-43)61-41-37(53)35(51)29(48)18-55-41/h8,19-22,25-43,48-54H,9-18H2,1-7H3/t19-,20+,21+,22-,25-,26-,27+,28+,29-,30+,31-,32+,33+,34+,35+,36-,37-,38-,39+,40-,41+,42+,43-,44+,45+,46-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ophiopogonin C

The roots of Ophiopogon japonicus

Biological Activity of Ophiopogonin C

DescriptionOphiopogonin C' pharmacological activities may be related to the substances in nucleus mainly.

Protocol of Ophiopogonin C

Structure Identification
Pharmaceutical Biotechnology, 2013-04

Study on the distribution in cells by Ophiopogonin C.[Reference: WebLink]

To investigate the effect and its feature of location and accumulation of Ophiopogonin C(DT-13) in HUVEC/HeLa cells moreover, a new method for the study of efficacy and mechanism of saponins of Traditional Chinese medicine(TCM) is provided.
METHODS AND RESULTS:
We obtaind and purified enough DT-13 monoclonal antibodies with the pre-obtained DT-13 hybridoma cell line 1B12, its activities with icELISA are also detectad. The effect of proliferation on HUVEC/HeLa cells after DT-13 with different series of concentrations by MTT assay is investigated. The effect and its feature of location and accumulation of DT-13 in HUVEC/HeLa cells by immunflouresence(FITC & DAPI staining) method and studied. The results showed that under the no-cytotoxicitiy concentration of DT-13, it can be carried thraugh in to cells' cytoplasm quickly and then got into nucleus gradually and accumulated for a long time. When in HUVEC cells, DT-13 (5.0 μmol/L) is in cytoplasm 30 min before, 12 h later it is basically all into the nucleus accumulating for at least 24 h. While in HeLa cells, DT-13 (2.5 μmol/L) is faster to get into nucleus than in HUVEC cells, slao accumulate for at least 24 h.
CONCLUSIONS:
The resluts suggest that DT-13' pharmacological activities may be related to the substances in nucleus mainly, and DT-13' main mechanism remains to be further studied. In summary, DT-13' localization and dynamic process in cells can be detected by this method with the advantage of direct-viewing, reliability and convenience. Also, this method can be referred when studying on other saponins of TCM or their analogues.

Ophiopogonin C Dilution Calculator

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Ophiopogonin C Molarity Calculator

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Preparing Stock Solutions of Ophiopogonin C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1148 mL 5.5738 mL 11.1475 mL 22.2951 mL 27.8688 mL
5 mM 0.223 mL 1.1148 mL 2.2295 mL 4.459 mL 5.5738 mL
10 mM 0.1115 mL 0.5574 mL 1.1148 mL 2.2295 mL 2.7869 mL
50 mM 0.0223 mL 0.1115 mL 0.223 mL 0.4459 mL 0.5574 mL
100 mM 0.0111 mL 0.0557 mL 0.1115 mL 0.223 mL 0.2787 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ophiopogonin C

[HPLC simultaneous determination of contents of 5 saponin constituents in Ophiopogonis Radix].[Pubmed:27062821]

Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):4022-5.

This research is to establish an HPLC method for the simultaneous determination of ophiopogonin D, ophiopogonin D', Ophiopogonin C, deacetylophiopojaponin A and ophiogenin-3-O-alpha-L-rhamnosyl-(1-->2)-beta-D-glucoside in Ophiopogonis Radix. HPLC-ELSD analysis was performed on a Kromasil 100-5 C(1)(8) column (4.6 mm x 250 mm, 5 microm), with the mobile phase of acetonitrile (A) -water (B) in gradient elution mode (0-45 min, 35%-55% A), at a flow rate of 1 mL . min(-)(1). The column temperature was 35 degrees C and the drift tube temperature was 100 degrees C in a gas flow rate of 3.0 L . min(-)(1). The result showed that baseline of all the 5 constituents was well separated, and every constituent had wide linearity range and good linear relation (r > 0.999). The recovery rate was between 95.75% and 103.1%. The new established method for simultaneous determination of saponin constituents in Ophiopogonis Radix was sensitive and has good, repeatability. It could be applied to quality evaluation of Ophiopogonis Radix.

Description

Ophiopojaponin C is a naturally occurring C29 steroidal glycoside isolated from the tubers of O. japonicas.

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