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Liriope muscari baily saponins C

CAS# 87480-46-4

Liriope muscari baily saponins C

Catalog No. BCN2340----Order now to get a substantial discount!

Product Name & Size Price Stock
Liriope muscari baily saponins C: 5mg $46 In Stock
Liriope muscari baily saponins C: 10mg Please Inquire In Stock
Liriope muscari baily saponins C: 20mg Please Inquire Please Inquire
Liriope muscari baily saponins C: 50mg Please Inquire Please Inquire
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Chemical structure

Liriope muscari baily saponins C

3D structure

Chemical Properties of Liriope muscari baily saponins C

Cas No. 87480-46-4 SDF Download SDF
PubChem ID 14682468 Appearance Powder
Formula C44H70O14 M.Wt 823.0
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[5-hydroxy-6-(hydroxymethyl)-2-(5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl)oxy-4-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
SMILES CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)OC8C(C(C(CO8)O)O)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C)OC1
Standard InChIKey DQYACEDUQHWXQZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C44H70O16/c1-19-8-13-44(54-17-19)20(2)30-28(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)56-41-38(59-40-36(52)34(50)31(47)21(3)55-40)37(33(49)29(16-45)57-41)58-39-35(51)32(48)27(46)18-53-39/h6,19-21,23-41,45-52H,7-18H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Liriope muscari baily saponins C

The roots of Liriope muscari

Biological Activity of Liriope muscari baily saponins C

DescriptionLiriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.
TargetsIL Receptor
In vivo

Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari.[Pubmed: 23833374]

Indian J Pharmacol. 2013 May-Jun; 45(3): 283–285.

To investigate the anti-thrombotic activity of DT-13(Liriope muscari baily saponins C) in experimental animal models.
METHODS AND RESULTS:
The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats.
CONCLUSIONS:
DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.

Protocol of Liriope muscari baily saponins C

Structure Identification
《Pharmaceutical Care and Research》 2007-06

Preparation of liriope muscari baily saponins C solid lipid nanoparticles[Reference: WebLink]

To prepare Liriope muscari baily saponins C solid lipid nanoparticles(DT-13-SLN) and to assess their physico-chemical characteristics.
METHODS AND RESULTS:
DT-13-SLN was prepared by the emulsification-solvent evaporation method.The formulation and the preparation technology of Liriope muscari baily saponins C solid lipid nanoparticles were optimized by the orthogonal design,the morphology was examined by the transmission electron microscope.The diameter,entrapment efficiency,drug loading, zeta potential and stability of Liriope muscari baily saponins C solid lipid nanoparticles were investigated. The average diameter of Liriope muscari baily saponins C solid lipid nanoparticles was 128.8 nm,the zeta potential was-30.0 mV,the entrapment efficiency was 57.43% and the drug loading was 3.48%.There were no notable changes of the particle size and entrapment efficiency at 4 ℃ within one month.New substance was examined by differential scanning calorimetery(DSC) analysis of Liriope muscari baily saponins C solid lipid nanoparticles.
CONCLUSIONS:
Liriope muscari baily saponins C solid lipid nanoparticles shows a narrow particle size distribution and good stability.

Liriope muscari baily saponins C Dilution Calculator

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Liriope muscari baily saponins C Molarity Calculator

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Preparing Stock Solutions of Liriope muscari baily saponins C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2151 mL 6.0753 mL 12.1507 mL 24.3013 mL 30.3767 mL
5 mM 0.243 mL 1.2151 mL 2.4301 mL 4.8603 mL 6.0753 mL
10 mM 0.1215 mL 0.6075 mL 1.2151 mL 2.4301 mL 3.0377 mL
50 mM 0.0243 mL 0.1215 mL 0.243 mL 0.486 mL 0.6075 mL
100 mM 0.0122 mL 0.0608 mL 0.1215 mL 0.243 mL 0.3038 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Liriope muscari baily saponins C

Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari.[Pubmed:23833374]

Indian J Pharmacol. 2013 May-Jun;45(3):283-5.

OBJECTIVE: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. MATERIALS AND METHODS: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. RESULTS: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. CONCLUSIONS: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.

Description

Liriope muscari baily saponins C is one of major active compounds of L. muscari (Decne.) Baily. Liriope muscari baily saponins C possesses strong anti-inflammatory, immunopharmacological and cardioprotective activities. Liriope muscari baily saponins C has been studied as a candidate drug for cancer metastasis.

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