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Sprengerinin A

CAS# 88866-99-3

Sprengerinin A

Catalog No. BCN6658----Order now to get a substantial discount!

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Quality Control of Sprengerinin A

Quality Control & MSDS

Number of papers citing our products

Chemical structure

Sprengerinin A

3D structure

Chemical Properties of Sprengerinin A

Cas No. 88866-99-3 SDF Download SDF
PubChem ID 137346024 Appearance Powder
Formula C38H60O12 M.Wt 708.9
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(4S,5'R,6R,7S,8R,9S,13R,16R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxyoxane-3,4,5-triol
SMILES CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(CO8)O)O)O)O)O)C)C)C)OC1
Standard InChIKey SNJAEJPQJPMZDC-RANLDERJSA-N
Standard InChI InChI=1S/C38H60O12/c1-18-7-12-38(46-16-18)19(2)28-26(50-38)14-24-22-6-5-20-13-21(8-10-36(20,3)23(22)9-11-37(24,28)4)47-35-32(44)30(42)33(27(15-39)48-35)49-34-31(43)29(41)25(40)17-45-34/h5,18-19,21-35,39-44H,6-17H2,1-4H3/t18-,19+,21-,22?,23?,24?,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35-,36+,37+,38-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Sprengerinin A

The tuber of Ophiopogon japonicus

Biological Activity of Sprengerinin A

In vitro

Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.[Reference: WebLink]

European Journal of Pharmacology, 2013, 714(1-3):261-273.

The multi-targeted therapy for liver cancer has been considered as a novel strategy to fight hepatocellular carcinoma.
METHODS AND RESULTS:
In this study, we first found that sprengerinin C, a naturally derived compound strongly suppressed tumor angiogenesis in human umbilical vein endothelial cells. A mechanism study revealed that sprengerinin C blocked vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways, two major pathways for tumor angiogenesis. Moreover, sprengerinin C inhibited vascular endothelial growth factor release, a vital event for early angiogenesis response, from hypoxic HepG-2/BEL7402 cells by suppressing hypoxia-inducible factor-1α transcriptional activity. Furthermore, sprengerinin C induced HepG-2/BEL7402 cell apoptosis by activating NADPH oxidase/reactive oxygen species-dependent caspase apoptosis pathway and suppressed HepG-2/BEL7402 cell growth through p53-mediated G2/M-phase arrest. Sprengerinin C also showed a significant anti-tumor effect in the nude mouse xenograft model of human hepatocellular carcinoma.
CONCLUSIONS:
These results provide new insights into development of potent candidate compounds for liver cancer through affecting multiple tumor progression steps of angiogenesis, apoptosis and proliferation.

Sprengerinin A Dilution Calculator

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Sprengerinin A Molarity Calculator

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Preparing Stock Solutions of Sprengerinin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4106 mL 7.0532 mL 14.1064 mL 28.2127 mL 35.2659 mL
5 mM 0.2821 mL 1.4106 mL 2.8213 mL 5.6425 mL 7.0532 mL
10 mM 0.1411 mL 0.7053 mL 1.4106 mL 2.8213 mL 3.5266 mL
50 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.5643 mL 0.7053 mL
100 mM 0.0141 mL 0.0705 mL 0.1411 mL 0.2821 mL 0.3527 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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