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(25RS)-Ruscogenin

CAS# 874485-32-2

(25RS)-Ruscogenin

Catalog No. BCN7805----Order now to get a substantial discount!

Product Name & Size Price Stock
(25RS)-Ruscogenin: 5mg $40 In Stock
(25RS)-Ruscogenin: 10mg Please Inquire In Stock
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Quality Control of (25RS)-Ruscogenin

Number of papers citing our products

Chemical structure

(25RS)-Ruscogenin

3D structure

Chemical Properties of (25RS)-Ruscogenin

Cas No. 874485-32-2 SDF Download SDF
PubChem ID 24849056 Appearance Powder
Formula C27H42O4 M.Wt 430.62
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,2S,4S,6R,7S,8R,9S,12S,13R,14R,16R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
SMILES CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)O)C)C)C)OC1
Standard InChIKey QMQIQBOGXYYATH-ZBTLHKOBSA-N
Standard InChI InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15?,16-,18+,19+,20-,21-,22-,23+,24-,25-,26-,27+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (25RS)-Ruscogenin

The leaves of Nolina microcarpa S. Wats.

Biological Activity of (25RS)-Ruscogenin

In vitro

DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway.[Pubmed: 28855900 ]

Frontiers in Immunology, 2017, 8:925.

DT-13((25RS)-Ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain unclear.
METHODS AND RESULTS:
Hence, this study was undertaken to elucidate the protective effect of DT-13 on TNF-α-induced endothelial permeability and the underlying mechanisms in vivo and in vitro. The in vivo results showed that DT-13 could ameliorate endothelial permeability in mustard oil-induced plasma leakage in the skin and modulate ZO-1 organization. In addition, the in vitro results showed that pretreatment with DT-13 could increase the transendothelial electrical resistance value and decrease the sodium fluorescein permeability coefficient. Moreover, DT-13 altered the mRNA and protein levels of ZO-1 as determined by real-time PCR, Western blotting, and immunofluorescence analyses. DT-13 treatment decreased the phosphorylations of Src, PI3K, and Akt in TNF-α-treated human umbilical vein endothelial cells (HUVECs). Further analyses with PP2 (10 µM, inhibitor of Src) indicated that DT-13 modulated endothelial permeability in TNF-α-induced HUVECs in an Src-dependent manner. LY294002 (10 µM, PI3K inhibitor) also had the same effect on DT-13 but did not affect phosphorylation of Src. Following decreased expression of non-muscle myosin IIA (NMIIA), the effect of DT-13 on the phosphorylations of Src, PI3K, and Akt was abolished.
CONCLUSIONS:
This study provides pharmacological evidence showing that DT-13 significantly ameliorated the TNF-α-induced vascular endothelial hyperpermeability through modulation of the Src/PI3K/Akt pathway and NMIIA, which play an important role in this process.

(25RS)-Ruscogenin Dilution Calculator

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(25RS)-Ruscogenin Molarity Calculator

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Preparing Stock Solutions of (25RS)-Ruscogenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3222 mL 11.6112 mL 23.2223 mL 46.4447 mL 58.0558 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL 9.2889 mL 11.6112 mL
10 mM 0.2322 mL 1.1611 mL 2.3222 mL 4.6445 mL 5.8056 mL
50 mM 0.0464 mL 0.2322 mL 0.4644 mL 0.9289 mL 1.1611 mL
100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.4644 mL 0.5806 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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