Neoruscogenin

CAS# 17676-33-4

Neoruscogenin

Catalog No. BCN8168----Order now to get a substantial discount!

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Quality Control of Neoruscogenin

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Chemical structure

Neoruscogenin

3D structure

Chemical Properties of Neoruscogenin

Cas No. 17676-33-4 SDF Download SDF
PubChem ID 9910474 Appearance Powder
Formula C27H40O4 M.Wt 428.61
Type of Compound Steroids Storage Desiccate at -20°C
Synonyms 25(27)-Dehydroruscogenin
Solubility Soluble in ethanol and methanol; slightly soluble in water
SMILES CC1C2C(CC3C2(CCC4C3CC=C5C4(C(CC(C5)O)O)C)C)OC16CCC(=C)CO6
Standard InChIKey ALTRINCJVPIQNK-NHIXJPGBSA-N
Standard InChI InChI=1S/C27H40O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,16,18-24,28-29H,1,6-14H2,2-4H3/t16-,18+,19+,20-,21-,22-,23+,24-,25-,26-,27+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neoruscogenin

The herbs of Ruscus aculeatus

Biological Activity of Neoruscogenin

Description1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.

Neoruscogenin Dilution Calculator

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Neoruscogenin Molarity Calculator

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Preparing Stock Solutions of Neoruscogenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3331 mL 11.6656 mL 23.3312 mL 46.6625 mL 58.3281 mL
5 mM 0.4666 mL 2.3331 mL 4.6662 mL 9.3325 mL 11.6656 mL
10 mM 0.2333 mL 1.1666 mL 2.3331 mL 4.6662 mL 5.8328 mL
50 mM 0.0467 mL 0.2333 mL 0.4666 mL 0.9332 mL 1.1666 mL
100 mM 0.0233 mL 0.1167 mL 0.2333 mL 0.4666 mL 0.5833 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neoruscogenin

Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells.[Pubmed:23499166]

Phytochemistry. 2013 Jun;90:106-13.

Rusci rhizoma extracts are traditionally used against chronic venous disorders (CVD). To determine the effect of its secondary plant metabolites on the endothelium, phenolic compounds and saponins from Butcher's broom were isolated from a methanolic extract, and their activity on the thrombin-induced hyperpermeability of human microvascular endothelial cells (HMEC-1) was investigated in vitro. In addition to the six known spirostanol saponins deglucoruscin (5), 22-O-methyl-deglucoruscoside (6), deglucoruscoside (7), ruscin (8), ruscogenin-1-O-(alpha-l-rhamnopyranosyl-(1-->2)-beta-d-galactopyranoside (9) and 1-O-sulpho-ruscogenin (10), three new spirostanol derivatives were isolated and identified: 3'-O-acetyl-4'-O-sulphodeglucoruscin (1), 4'-O-(2-hydroxy-3-methylpentanoyl)-deglucoruscin (2) and 4'-O-acetyl-deglucoruscin (3). Furthermore, the coumarin esculin (4), which is also prominently present in other medicinal plants used in the treatment of CVD, was isolated for the first time from Rusci rhizoma. Five of the isolated steroid derivatives (2, 5, 8, 9 and 10) and esculin (4) were tested for their ability to reduce the thrombin-induced hyperpermeability of endothelial cells in vitro, and the results were compared to those of the aglycone Neoruscogenin (11). The latter compound showed a slight but concentration-dependent reduction in hyperpermeability to 71.8% at 100muM. The highest activities were observed for the spirostanol saponins 5 and 8 and for esculin (4) at 10muM, and these compounds resulted in a reduction of the thrombin-induced hyperpermeability to 41.9%, 42.6% and 53.3%, respectively. For 2, 5 and 8, the highest concentration tested (100muM) resulted in a drastic increase of the thrombin effect. The effect of esculin observed at a concentration of 10muM was diminished at 100muM. These in vitro data provide insight into the pharmacological mechanism by which the genuine spirostanol saponins and esculin can contribute to the efficacy of Butcher's broom against chronic venous disorders.

The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORalpha (NR1F1).[Pubmed:23896689]

J Biomol Screen. 2014 Mar;19(3):399-406.

Plants represent a tremendous structural diversity of natural compounds that bind to many different human disease targets and are potentially useful as starting points for medicinal chemistry programs. This resource is, however, still underexploited due to technical difficulties with the identification of minute quantities of active ingredients in complex mixtures of structurally diverse compounds upon raw phytomass extraction. In this work, we describe the successful identification of a novel class of potent RAR-related orphan receptor alpha (RORalpha or nuclear receptor NR1F1) agonists from a library of 12,000 plant extract fractions by using an optimized, robust high-throughput cell-free screening method, as well as an innovative hit compound identification procedure through further extract deconvolution and subsequent structural elucidation of the active natural compound(s). In particular, we demonstrate that Neoruscogenin, a member of the steroidal sapogenin family, is a potent and high-affinity RORalpha agonist, as shown by its activity in RORalpha reporter assays and from its effect on RORalpha target gene expression in vitro and in vivo. Neoruscogenin represents a universal pharmacological tool for RORalpha research due to its specific selectivity profile versus other nuclear receptors, its excellent microsomal stability, good bioavailability, and significant peripheral exposure in mouse.

Description

Neoruscogenin, a member of the steroidal sapogenin family, is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).

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