11(13)-DehydroivaxillinCAS# 87441-73-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 87441-73-4 | SDF | Download SDF |
| PubChem ID | 435723 | Appearance | Powder |
| Formula | C15H20O4 | M.Wt | 264.3 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC12CCC3C(O3)(CC4C(CC1O2)C(=C)C(=O)O4)C | ||
| Standard InChIKey | SSZZFAJCDFWCJW-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Carpesium abrotanoides L.
| Description | 1. 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy. |
| Targets | Antifection |
11(13)-Dehydroivaxillin Dilution Calculator
11(13)-Dehydroivaxillin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7836 mL | 18.9179 mL | 37.8358 mL | 75.6716 mL | 94.5895 mL |
| 5 mM | 0.7567 mL | 3.7836 mL | 7.5672 mL | 15.1343 mL | 18.9179 mL |
| 10 mM | 0.3784 mL | 1.8918 mL | 3.7836 mL | 7.5672 mL | 9.4589 mL |
| 50 mM | 0.0757 mL | 0.3784 mL | 0.7567 mL | 1.5134 mL | 1.8918 mL |
| 100 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.7567 mL | 0.9459 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.[Pubmed:18608780]
J Enzyme Inhib Med Chem. 2009 Feb;24(1):247-50.
The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)- dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae). Here, the antimalarial activity of DDV was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. DDV (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. DDV possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
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