Adapalene sodium saltCAS# 911110-93-5 |
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| Cas No. | 911110-93-5 | SDF | Download SDF |
| PubChem ID | 66755369 | Appearance | Powder |
| Formula | C28H27NaO3 | M.Wt | 434.5 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | CD 271 sodium salt | ||
| Solubility | Soluble in DMSO | ||
| Chemical Name | 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid;sodium | ||
| SMILES | COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5.[Na] | ||
| Standard InChIKey | JGZYHPLAOKOZHY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C28H28O3.Na/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28;/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30); | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).
Target: Retinoic acid receptor agonist (RAR)
Adapalene sodium salt is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene sodium salt is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].
Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene sodium salt group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than adapalene sodium salt and controls (P < 0.05). Adapalene sodium salt was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].
Clinical indications: Acne; Purpura; Sunburn
FDA Approved Date: 1996
Toxicity: Skin redness; dryness; itching; scaling; mild burning References: | |||||
Adapalene sodium salt Dilution Calculator
Adapalene sodium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3015 mL | 11.5075 mL | 23.015 mL | 46.0299 mL | 57.5374 mL |
| 5 mM | 0.4603 mL | 2.3015 mL | 4.603 mL | 9.206 mL | 11.5075 mL |
| 10 mM | 0.2301 mL | 1.1507 mL | 2.3015 mL | 4.603 mL | 5.7537 mL |
| 50 mM | 0.046 mL | 0.2301 mL | 0.4603 mL | 0.9206 mL | 1.1507 mL |
| 100 mM | 0.023 mL | 0.1151 mL | 0.2301 mL | 0.4603 mL | 0.5754 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).
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Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).
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