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Isotussilagine

CAS# 91108-32-6

Isotussilagine

Catalog No. BCN1985----Order now to get a substantial discount!

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Quality Control of Isotussilagine

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Chemical structure

Isotussilagine

3D structure

Chemical Properties of Isotussilagine

Cas No. 91108-32-6 SDF Download SDF
PubChem ID 149801 Appearance Powder
Formula C10H17NO3 M.Wt 199.25
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (1S,2R,8S)-2-hydroxy-2-methyl-1,3,5,6,7,8-hexahydropyrrolizine-1-carboxylate
SMILES CC1(CN2CCCC2C1C(=O)OC)O
Standard InChIKey LADVYSUMGRTFSZ-XKSSXDPKSA-N
Standard InChI InChI=1S/C10H17NO3/c1-10(13)6-11-5-3-4-7(11)8(10)9(12)14-2/h7-8,13H,3-6H2,1-2H3/t7-,8+,10-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isotussilagine

The herb of Echinacea purpurea.

Biological Activity of Isotussilagine

In vitro

Tussilagine and isotussilagine: two pyrrolizidine alkaloids in the genus arnica1.[Pubmed: 17226521]

Planta Med. 1992 Dec;58(6):556-7.


METHODS AND RESULTS:
In flowerheads of ARNICA MONTANA, A. CHAMISSONIS ssp. FOLIOSA, A. AMPLEXICAULIS, and A. SACHALINENSIS, traces of the non-toxic pyrrolizidine alkaloids tussilagine and Isotussilagine were detected.
CONCLUSIONS:
Their identity was unambiguously confirmed by direct comparison (TLC, GC, GC/MS) with the authentic samples.

Protocol of Isotussilagine

Structure Identification
Tetrahedron Letters,1998,39(49): 9067–9068.

Enantioselective syntheses of tussilagine and isotussilagine[Reference: WebLink]


METHODS AND RESULTS:
Tussilagine and Isotussilagine are synthesized through the coupling reactions of N,N-disubstituted β-amino-esters with methyl pyruvate and Mitsunobu reactions as key steps.
CONCLUSIONS:
The first enantioselective syntheses of tussilagine and Isotussilagine via the coupling reactions of N,N-disubstituted β-amino esters with methyl pyruvate are described.

Isotussilagine Dilution Calculator

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Isotussilagine Molarity Calculator

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Preparing Stock Solutions of Isotussilagine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0188 mL 25.0941 mL 50.1882 mL 100.3764 mL 125.4705 mL
5 mM 1.0038 mL 5.0188 mL 10.0376 mL 20.0753 mL 25.0941 mL
10 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
50 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.0075 mL 2.5094 mL
100 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isotussilagine

Tussilagine and isotussilagine: two pyrrolizidine alkaloids in the genus arnica1.[Pubmed:17226521]

Planta Med. 1992 Dec;58(6):556-7.

In flowerheads of ARNICA MONTANA, A. CHAMISSONIS ssp. FOLIOSA, A. AMPLEXICAULIS, and A. SACHALINENSIS, traces of the non-toxic pyrrolizidine alkaloids tussilagine and Isotussilagine were detected. Their identity was unambiguously confirmed by direct comparison (TLC, GC, GC/MS) with the authentic samples.

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