Tussilagine

CAS# 80151-77-5

Tussilagine

Catalog No. BCN1984----Order now to get a substantial discount!

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Quality Control of Tussilagine

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Chemical structure

Tussilagine

3D structure

Chemical Properties of Tussilagine

Cas No. 80151-77-5 SDF Download SDF
PubChem ID 185071 Appearance Powder
Formula C10H17NO3 M.Wt 199.25
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (1S,2S,8S)-2-hydroxy-2-methyl-1,3,5,6,7,8-hexahydropyrrolizine-1-carboxylate
SMILES CC1(CN2CCCC2C1C(=O)OC)O
Standard InChIKey LADVYSUMGRTFSZ-QXFUBDJGSA-N
Standard InChI InChI=1S/C10H17NO3/c1-10(13)6-11-5-3-4-7(11)8(10)9(12)14-2/h7-8,13H,3-6H2,1-2H3/t7-,8+,10+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tussilagine

The herb of Echinacea purpurea.

Biological Activity of Tussilagine

In vitro

Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine.[Reference: WebLink]

Planta Medica, 1998, 64(03):259-263.

Monoclonal antibodies against retrorsine were established using a retrorsine-hemisuccinate::bovine-thyroglobuline conjugate as antigen for immunization.
METHODS AND RESULTS:
In competitive enzyme-linked immunoassays the specificity of the obtained antibodies was tested with 20 different pyrrolizidine alkaloids. Among these the alkaloids acetylgynuramine, gynuramine, integerrimine, neoplatyphylline, platyphylline, rosmarinine, senecionine, and seneciphylline were able to bind the antibody. There was no cross-reactivity with the alkaloids senkirkine, angeloylheliotridine, heliotridine, axillarine, anacrotine, monocrotaline, madurensine, otosenine, retronecine, Tussilagine, triangularine, and jacoline as well as with seneciphylline N-oxide.
CONCLUSIONS:
From this antigen spectrum it can be concluded that besides the necic structure itself the dominant and discriminative epitope consists of the exocyclic ethylidene group of the various diesters.

Protocol of Tussilagine

Structure Identification
Phytochemistry, 1992, 31(12):4135-4137.

Co-occurrence of 2-pyrrolidineacetic acid with the pyrrolizidines tussilaginic acid and isotussilaginic acid and their 1-epimers in Arnica species and Tussilago farfara.[Reference: WebLink]


METHODS AND RESULTS:
Flowerheads of Arnica montana, A. chamissonis ssp. foliosa, A. amplexicaulis and A. sachalinensis contained, in addition to the pyrrolizidine alkaloids, tussilaginic acid and isotussilaginic acid, 2-pyrrolidineacetic acid and the C-1 epimers of the two pyrrolizidine acids. Biosynthetic aspects are discussed on the basis of this co-occurrence.
CONCLUSIONS:
The pyrrolizidines Tussilagine and isoTussilagine, formerly reported for Asteraceae species, are artefacts caused by Soxhlet extraction with methanol.

Tussilagine Dilution Calculator

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Tussilagine Molarity Calculator

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Preparing Stock Solutions of Tussilagine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0188 mL 25.0941 mL 50.1882 mL 100.3764 mL 125.4705 mL
5 mM 1.0038 mL 5.0188 mL 10.0376 mL 20.0753 mL 25.0941 mL
10 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
50 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.0075 mL 2.5094 mL
100 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tussilagine

Tussilagine and isotussilagine: two pyrrolizidine alkaloids in the genus arnica1.[Pubmed:17226521]

Planta Med. 1992 Dec;58(6):556-7.

In flowerheads of ARNICA MONTANA, A. CHAMISSONIS ssp. FOLIOSA, A. AMPLEXICAULIS, and A. SACHALINENSIS, traces of the non-toxic pyrrolizidine alkaloids Tussilagine and isoTussilagine were detected. Their identity was unambiguously confirmed by direct comparison (TLC, GC, GC/MS) with the authentic samples.

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