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Dihydrocholesterol

CAS# 80-97-7

Dihydrocholesterol

Catalog No. BCN2749----Order now to get a substantial discount!

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Quality Control of Dihydrocholesterol

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Chemical structure

Dihydrocholesterol

3D structure

Chemical Properties of Dihydrocholesterol

Cas No. 80-97-7 SDF Download SDF
PubChem ID 3240 Appearance Powder
Formula C27H48O M.Wt 388.67
Type of Compound Steroids Storage Desiccate at -20°C
Solubility H2O : < 0.1 mg/mL (insoluble)
DMSO : 1 mg/mL (2.57 mM; ultrasonic and warming and heat to 60°C)
Chemical Name 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
Standard InChIKey QYIXCDOBOSTCEI-UHFFFAOYSA-N
Standard InChI InChI=1S/C27H48O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-25,28H,6-17H2,1-5H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Dihydrocholesterol

DescriptionDihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Dihydrocholesterol is equally effective in reducing plasma cholesterol as β-sitosterol at a low dose, which is mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.
In vivo

Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury.[Pubmed: 383127]

Br J Exp Pathol. 1979 Jun;60(3):231-8.

Rabbits fed a diet containing 0.75% Dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder.
METHODS AND RESULTS:
In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological changes was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells.
CONCLUSIONS:
It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholelithiasis.

Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.[Pubmed: 26184696 ]

Atherosclerosis. 2015 Sep;242(1):77-86.

Cholesterol analogs have been used to treat hypercholesterolemia. The present study was to examine the effect of Dihydrocholesterol (DC) on plasma total cholesterol (TC) compared with that of β-sitosterol (SI) in hamsters fed a high cholesterol diet.
METHODS AND RESULTS:
Forty-five male hamsters were randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of five high-cholesterol diets without addition of DC and SI (HCD) or with addition of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could increase the excretion of fecal sterols, however, DC was more effective in increasing the excretion of neutral sterols but it was less effective in increasing the excretion of acidic sterols compared with SI. Results on the incorporation of sterols in micellar solutions clearly demonstrated both DC and SI could displace the cholesterol from micelles with the former being more effective than the latter.
CONCLUSIONS:
DC was equally effective in reducing plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

Dihydrocholesterol Dilution Calculator

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Dihydrocholesterol Molarity Calculator

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Preparing Stock Solutions of Dihydrocholesterol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5729 mL 12.8644 mL 25.7288 mL 51.4575 mL 64.3219 mL
5 mM 0.5146 mL 2.5729 mL 5.1458 mL 10.2915 mL 12.8644 mL
10 mM 0.2573 mL 1.2864 mL 2.5729 mL 5.1458 mL 6.4322 mL
50 mM 0.0515 mL 0.2573 mL 0.5146 mL 1.0292 mL 1.2864 mL
100 mM 0.0257 mL 0.1286 mL 0.2573 mL 0.5146 mL 0.6432 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dihydrocholesterol

Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.[Pubmed:26184696]

Atherosclerosis. 2015 Sep;242(1):77-86.

OBJECTIVE: Cholesterol analogs have been used to treat hypercholesterolemia. The present study was to examine the effect of Dihydrocholesterol (DC) on plasma total cholesterol (TC) compared with that of beta-sitosterol (SI) in hamsters fed a high cholesterol diet. METHODS AND RESULTS: Forty-five male hamsters were randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of five high-cholesterol diets without addition of DC and SI (HCD) or with addition of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could increase the excretion of fecal sterols, however, DC was more effective in increasing the excretion of neutral sterols but it was less effective in increasing the excretion of acidic sterols compared with SI. Results on the incorporation of sterols in micellar solutions clearly demonstrated both DC and SI could displace the cholesterol from micelles with the former being more effective than the latter. CONCLUSION: DC was equally effective in reducing plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury.[Pubmed:383127]

Br J Exp Pathol. 1979 Jun;60(3):231-8.

Rabbits fed a diet containing 0.75% Dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder. In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological changes was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells. It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholelithiasis.

Description

5α-Cholestan-3β-ol is a derivitized steroid compound, which is isolated from the testes of White Carneau pigeons.

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