Methylophiopogonanone ACAS# 74805-92-8 |
Quality Control & MSDS
Number of papers citing our products
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Chemical structure
![Methylophiopogonanone A](/media/images/struct/BCN5417.png)
3D structure
Cas No. | 74805-92-8 | SDF | Download SDF |
PubChem ID | 53466984 | Appearance | Light yellow powder |
Formula | C19H18O6 | M.Wt | 342.34 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Solubility | Soluble in chloroform and methanol; insoluble in water | ||
Chemical Name | (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one | ||
SMILES | CC1=C(C2=C(C(=C1O)C)OCC(C2=O)CC3=CC4=C(C=C3)OCO4)O | ||
Standard InChIKey | BXTNNJIQILYHJB-GFCCVEGCSA-N | ||
Standard InChI | InChI=1S/C19H18O6/c1-9-16(20)10(2)19-15(17(9)21)18(22)12(7-23-19)5-11-3-4-13-14(6-11)25-8-24-13/h3-4,6,12,20-21H,5,7-8H2,1-2H3/t12-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties, it also has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins. |
Targets | MMP(e.g.TIMP) |
In vivo | Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro.[Pubmed: 25897666]PLoS One. 2015 Apr 21;10(4):e0124558.Methylophiopogonanone A (MO-A), an active homoisoflavonoid of the Chinese herb Ophiopogon japonicus which has been shown to have protective effects on cerebral ischemia/reperfusion (I/R) injury, has been demonstrated to have anti-inflammatory and anti-oxidative properties. However, little is known about its role in cerebral I/R injury. |
Structure Identification | Chinese Traditional & Herbal Drugs, 2015, 46(20):3091-5.Comparison on homoisoflavones extracted from Ophiopogon japonicus in Sichuan and Zhejiang and their anti-oxidative activity.[Reference: WebLink]To compare the contents of three homoisoflavones and their anti-oxidative activity of Ophiopogon japonicus in Sichuan(OJS) and Zhejiang(OJZ). |
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Methylophiopogonanone A Dilution Calculator
![](/statics/images/closeICO.png)
Methylophiopogonanone A Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.9211 mL | 14.6054 mL | 29.2107 mL | 58.4215 mL | 73.0268 mL |
5 mM | 0.5842 mL | 2.9211 mL | 5.8421 mL | 11.6843 mL | 14.6054 mL |
10 mM | 0.2921 mL | 1.4605 mL | 2.9211 mL | 5.8421 mL | 7.3027 mL |
50 mM | 0.0584 mL | 0.2921 mL | 0.5842 mL | 1.1684 mL | 1.4605 mL |
100 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.5842 mL | 0.7303 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro.[Pubmed:25897666]
PLoS One. 2015 Apr 21;10(4):e0124558.
Methylophiopogonanone A (MO-A), an active homoisoflavonoid of the Chinese herb Ophiopogon japonicus which has been shown to have protective effects on cerebral ischemia/reperfusion (I/R) injury, has been demonstrated to have anti-inflammatory and anti-oxidative properties. However, little is known about its role in cerebral I/R injury. Therefore, in this study, by using a middle cerebral artery occlusion (MCAO) and reperfusion rat model, the effect of MO-A on cerebral I/R injury was examined. The results showed that MO-A treatment reduced infarct volume and brain edema, improved neurological deficit scores, reversed animal body weight decreases, and increased animal survival time in the stroke groups. Western blotting showed that MO-A suppressed MMP-9, but restored the expression of claudin-3 and claudin-5. Furthermore, transmission electron microscopy were monitored to determine the blood-brain barrier (BBB) alterations in vitro. The results showed that MO-A markedly attenuated BBB damage in vitro. Additionally, MO-A inhibited ROS production in ECs and MMP-9 release in differentiated THP-1 cells in vitro, and suppressed ICAM-1 and VCAM-1 expression in ECs and leukocyte/EC adhesion. In conclusion, our data indicate that MO-A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins.