Moracin M

CAS# 56317-21-6

Moracin M

Catalog No. BCN3292----Order now to get a substantial discount!

Product Name & Size Price Stock
Moracin M: 5mg $598 In Stock
Moracin M: 10mg Please Inquire In Stock
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Quality Control of Moracin M

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Chemical structure

Moracin M

3D structure

Chemical Properties of Moracin M

Cas No. 56317-21-6 SDF Download SDF
PubChem ID 185848 Appearance Powder
Formula C14H10O4 M.Wt 242.2
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
SMILES C1=CC2=C(C=C1O)OC(=C2)C3=CC(=CC(=C3)O)O
Standard InChIKey LHPRYOJTASOZGJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Moracin M

The root bark of Morus alba L.

Biological Activity of Moracin M

Description1. Moracin M is a phytoalexin. 2. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
TargetsPDE

Moracin M Dilution Calculator

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Moracin M Molarity Calculator

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Preparing Stock Solutions of Moracin M

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1288 mL 20.6441 mL 41.2882 mL 82.5764 mL 103.2205 mL
5 mM 0.8258 mL 4.1288 mL 8.2576 mL 16.5153 mL 20.6441 mL
10 mM 0.4129 mL 2.0644 mL 4.1288 mL 8.2576 mL 10.322 mL
50 mM 0.0826 mL 0.4129 mL 0.8258 mL 1.6515 mL 2.0644 mL
100 mM 0.0413 mL 0.2064 mL 0.4129 mL 0.8258 mL 1.0322 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Moracin M

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed:22483586]

Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.

Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 muM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.

Description

Moracin M, a phenolic component in the skin of Morus alba L., is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity.

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