N-MethylflindersineCAS# 50333-13-6 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 50333-13-6 | SDF | Download SDF |
| PubChem ID | 72819 | Appearance | Powder |
| Formula | C15H15NO2 | M.Wt | 241.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2,2,6-trimethylpyrano[3,2-c]quinolin-5-one | ||
| SMILES | CC1(C=CC2=C(O1)C3=CC=CC=C3N(C2=O)C)C | ||
| Standard InChIKey | RJZFGBNKPOVCHQ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H15NO2/c1-15(2)9-8-11-13(18-15)10-6-4-5-7-12(10)16(3)14(11)17/h4-9H,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. N-Methylflindersine shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. 2. N-Methylflindersine exhibits potent inhibition against N -formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM. |
N-Methylflindersine Dilution Calculator
N-Methylflindersine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1442 mL | 20.7211 mL | 41.4422 mL | 82.8844 mL | 103.6055 mL |
| 5 mM | 0.8288 mL | 4.1442 mL | 8.2884 mL | 16.5769 mL | 20.7211 mL |
| 10 mM | 0.4144 mL | 2.0721 mL | 4.1442 mL | 8.2884 mL | 10.3605 mL |
| 50 mM | 0.0829 mL | 0.4144 mL | 0.8288 mL | 1.6577 mL | 2.0721 mL |
| 100 mM | 0.0414 mL | 0.2072 mL | 0.4144 mL | 0.8288 mL | 1.0361 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Alkaloids from the stem bark of Micromelum falcatum.[Pubmed:19483341]
Chem Pharm Bull (Tokyo). 2009 Jun;57(6):600-2.
Two new quinoldione alkaloids, methyl 2-(3-hydroxy-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl)acetate (1) and 3-hydroxy-1-methyl-3-(2-oxopropyl)quinoline-2,4(1H,3H)-dione (2), and two quinolinone alkaloids previously synthesized but first isolated as natural products, N-Methylflindersine (3) and 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (4), were isolated from the stem bark of Micromelum falcatum, together with the known N-methylswietenidine-B (5). Their structures were established mainly on the basis of 1D- and 2D-NMR techniques. All compounds were evaluated for toxicity towards brine shrimp larvae, and 3 showed strong toxicity with an LD(50) value of 1.39 microg/ml.
New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum.[Pubmed:17822293]
J Nat Prod. 2007 Sep;70(9):1444-8.
Five new compounds, including two new phenylpropenoids, (R,E)-1-[4-(3-hydroxyprop-1-enyl)phenoxy]-3-methylbutane-2,3-diol (1) and 4-hydroxy-3-(3-methyl-2-butenyl)cinnamyl alcohol (2), two new bis(1-phenylethyl)phenols, 2,6-bis(1-phenylethyl)phenol (3) and 2,4-bis(1-phenylethyl)phenol (4), and a new bisquinolinone alkaloid, 18-demethylparaensidimerin C (5), together with 17 known compounds have been isolated from the stem wood of Zanthoxylum integrifoliolum. The structures of these new compounds were determined through spectral analyses including extensive 2D nuclear magnetic resonance data. Among the isolates, N-Methylflindersine (7), (-)-simulanol (10), and evofolin-C (16) exhibited potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than 12 microM.
A novel 3,9-(1,2,3-trioxocine)-type steroid of Rauia nodosa (Rutaceae).[Pubmed:25230120]
Molecules. 2014 Sep 16;19(9):14637-48.
A new natural product, a 3,9-(1,2,3-trioxocine)-type steroid, named rauianodoxy (6), was isolated from Rauia nodosa, together with five steroids: sistostenone (1), stigmastenone (2), sitosterol (3), stigmasterol (4) and ergosterol peroxide (5), one coumarin, O-geranylosthenol (7), and three alkaloids, N-Methylflindersine (8), zantobungeanine (9) and veprissine (10). Compounds 5-8 were isolated for the first time in the genus Rauia. These compounds were characterized on the basis of their spectral data, mainly one and two-dimensional NMR, and mass spectra, also involving comparison with the literature data. Theoretical studies at the DFT level reveal structural parameters for the 1,2,3-trioxole bridge compatible with known structures containing a similar group.
