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Necrostatin 2 S enantiomer

In vitro necroptosis inhibitor CAS# 852391-20-9

Necrostatin 2 S enantiomer

Catalog No. BCC2078----Order now to get a substantial discount!

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Necrostatin 2 S enantiomer: 5mg $265 In Stock
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Quality Control of Necrostatin 2 S enantiomer

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Chemical structure

Necrostatin 2 S enantiomer

3D structure

Chemical Properties of Necrostatin 2 S enantiomer

Cas No. 852391-20-9 SDF Download SDF
PubChem ID 44404825 Appearance Powder
Formula C13H12ClN3O2 M.Wt 277.71
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 50 mg/mL (180.04 mM; Need ultrasonic)
Chemical Name (5S)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
Standard InChIKey WIKGAEMMNQTUGL-JTQLQIEISA-N
Standard InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Necrostatin 2 S enantiomer

DescriptionNecrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. IC50 Value: 50 nM (EC50) [1] Target: TNF-alpha Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

References:
[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. [2]. Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95. [3]. Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44.

Necrostatin 2 S enantiomer Dilution Calculator

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Necrostatin 2 S enantiomer Molarity Calculator

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Preparing Stock Solutions of Necrostatin 2 S enantiomer

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6009 mL 18.0044 mL 36.0088 mL 72.0176 mL 90.022 mL
5 mM 0.7202 mL 3.6009 mL 7.2018 mL 14.4035 mL 18.0044 mL
10 mM 0.3601 mL 1.8004 mL 3.6009 mL 7.2018 mL 9.0022 mL
50 mM 0.072 mL 0.3601 mL 0.7202 mL 1.4404 mL 1.8004 mL
100 mM 0.036 mL 0.18 mL 0.3601 mL 0.7202 mL 0.9002 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Necrostatin 2 S enantiomer

IC50 Value: 50 nM (EC50) [1] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

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Description

Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2.

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