Necrostatin 2 racemateIn vitro necroptosis inhibitor CAS# 852391-15-2 |
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| Cas No. | 852391-15-2 | SDF | Download SDF |
| PubChem ID | 643953 | Appearance | Powder |
| Formula | C13H12ClN3O2 | M.Wt | 277.71 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Necrostatin-2 racemate | ||
| Solubility | DMSO : ≥ 50 mg/mL (180.04 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | ||
| SMILES | CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl | ||
| Standard InChIKey | WIKGAEMMNQTUGL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
IC50 Value: 50 nM (EC50) [1]
Target: TNF-alpha
Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). References: | |||||
Necrostatin 2 racemate Dilution Calculator
Necrostatin 2 racemate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6009 mL | 18.0044 mL | 36.0088 mL | 72.0176 mL | 90.022 mL |
| 5 mM | 0.7202 mL | 3.6009 mL | 7.2018 mL | 14.4035 mL | 18.0044 mL |
| 10 mM | 0.3601 mL | 1.8004 mL | 3.6009 mL | 7.2018 mL | 9.0022 mL |
| 50 mM | 0.072 mL | 0.3601 mL | 0.7202 mL | 1.4404 mL | 1.8004 mL |
| 100 mM | 0.036 mL | 0.18 mL | 0.3601 mL | 0.7202 mL | 0.9002 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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IC50 Value: 50 nM (EC50) [1] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).
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Necrostatin 2 racemate (Nec-1S), the Nec-1 stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.
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