Home >> Research Area >>Apoptosis>>TNF-α>> Necrostatin 2 racemate

Necrostatin 2 racemate

In vitro necroptosis inhibitor CAS# 852391-15-2

Necrostatin 2 racemate

Catalog No. BCC2077----Order now to get a substantial discount!

Product Name & Size Price Stock
Necrostatin 2 racemate: 5mg $265 In Stock
Necrostatin 2 racemate: 10mg Please Inquire In Stock
Necrostatin 2 racemate: 20mg Please Inquire Please Inquire
Necrostatin 2 racemate: 50mg Please Inquire Please Inquire
Necrostatin 2 racemate: 100mg Please Inquire Please Inquire
Necrostatin 2 racemate: 200mg Please Inquire Please Inquire
Necrostatin 2 racemate: 500mg Please Inquire Please Inquire
Necrostatin 2 racemate: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Necrostatin 2 racemate

Number of papers citing our products

Chemical structure

Necrostatin 2 racemate

3D structure

Chemical Properties of Necrostatin 2 racemate

Cas No. 852391-15-2 SDF Download SDF
PubChem ID 643953 Appearance Powder
Formula C13H12ClN3O2 M.Wt 277.71
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Necrostatin-2 racemate
Solubility DMSO : ≥ 50 mg/mL (180.04 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
Standard InChIKey WIKGAEMMNQTUGL-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Necrostatin 2 racemate

DescriptionNecrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. IC50 Value: 50 nM (EC50) [1] Target: TNF-alpha Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

References:
[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. [2]. Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95. [3]. Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44.

Necrostatin 2 racemate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Necrostatin 2 racemate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Necrostatin 2 racemate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6009 mL 18.0044 mL 36.0088 mL 72.0176 mL 90.022 mL
5 mM 0.7202 mL 3.6009 mL 7.2018 mL 14.4035 mL 18.0044 mL
10 mM 0.3601 mL 1.8004 mL 3.6009 mL 7.2018 mL 9.0022 mL
50 mM 0.072 mL 0.3601 mL 0.7202 mL 1.4404 mL 1.8004 mL
100 mM 0.036 mL 0.18 mL 0.3601 mL 0.7202 mL 0.9002 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Necrostatin 2 racemate

IC50 Value: 50 nM (EC50) [1] Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins).

Featured Products
New Products
 

Description

Necrostatin 2 racemate (Nec-1S), the Nec-1 stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.

Keywords:

Necrostatin 2 racemate,852391-15-2,Necrostatin-2 racemate,Natural Products,TNF-α, buy Necrostatin 2 racemate , Necrostatin 2 racemate supplier , purchase Necrostatin 2 racemate , Necrostatin 2 racemate cost , Necrostatin 2 racemate manufacturer , order Necrostatin 2 racemate , high purity Necrostatin 2 racemate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: