RuBi-4APCaged 4-aminopyridine; a non-selective KV channel blocker CAS# 851956-02-0 |
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| Cas No. | 851956-02-0 | SDF | Download SDF |
| PubChem ID | 11422486 | Appearance | Powder |
| Formula | C30H28Cl2N8Ru | M.Wt | 672.58 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Rubi-4-aminopyridine | ||
| Solubility | Soluble to 30 mM in water | ||
| Chemical Name | pyridin-4-amine;2-pyridin-2-ylpyridine;ruthenium(2+);dichloride | ||
| SMILES | C1=CC=NC(=C1)C2=CC=CC=N2.C1=CC=NC(=C1)C2=CC=CC=N2.C1=CN=CC=C1N.C1=CN=CC=C1N.[Cl-].[Cl-].[Ru+2] | ||
| Standard InChIKey | MVEGPXUCOGNVKR-UHFFFAOYSA-L | ||
| Standard InChI | InChI=1S/2C10H8N2.2C5H6N2.2ClH.Ru/c2*1-3-7-11-9(5-1)10-6-2-4-8-12-10;2*6-5-1-3-7-4-2-5;;;/h2*1-8H;2*1-4H,(H2,6,7);2*1H;/q;;;;;;+2/p-2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP, a voltage-dependent K+ channel blocker. |
RuBi-4AP Dilution Calculator
RuBi-4AP Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4868 mL | 7.4341 mL | 14.8681 mL | 29.7362 mL | 37.1703 mL |
| 5 mM | 0.2974 mL | 1.4868 mL | 2.9736 mL | 5.9472 mL | 7.4341 mL |
| 10 mM | 0.1487 mL | 0.7434 mL | 1.4868 mL | 2.9736 mL | 3.717 mL |
| 50 mM | 0.0297 mL | 0.1487 mL | 0.2974 mL | 0.5947 mL | 0.7434 mL |
| 100 mM | 0.0149 mL | 0.0743 mL | 0.1487 mL | 0.2974 mL | 0.3717 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Optical triggered seizures using a caged 4-Aminopyridine.[Pubmed:25698919]
Front Neurosci. 2015 Feb 4;9:25.
Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions. Photorelease of caged molecules is widely used in biological research to control pharmacologic events with high spatio-temporal resolution. We developed a technique for in vivo optical triggering of neocortical seizures using a novel caged compound based on ruthenium photochemistry (RuBi-4AP). Epileptiform events in mouse cortex were induced with blue light in both whole brain and focal illumination. Multi-electrode array recording and optical techniques were used to characterize the propagation of these epileptic events, including interictal spikes, polyspikes, and ictal discharges. These results demonstrate a novel optically-triggered seizure model, with high spatio-temporal control, that could have widespread application in the investigation of ictal onset, propagation and to develop novel light-based therapeutic interventions.
A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage.[Pubmed:12537482]
J Am Chem Soc. 2003 Jan 29;125(4):882-3.
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.
