Amuvatinib (MP-470, HPK 56)Tyrosine kinase inhibitor CAS# 850879-09-3 |
Related Products
- Regorafenib monohydrate
Catalog No.:BCC1884
CAS No.:1019206-88-2
- SU5416
Catalog No.:BCC1974
CAS No.:204005-46-9
- Danusertib (PHA-739358)
Catalog No.:BCC2172
CAS No.:827318-97-8
- Regorafenib hydrochloride
Catalog No.:BCC1883
CAS No.:835621-07-3
- TG101209
Catalog No.:BCC2198
CAS No.:936091-14-4
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 850879-09-3 | SDF | Download SDF |
| PubChem ID | 11282283 | Appearance | Powder |
| Formula | C23H21N5O3S | M.Wt | 447.51 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | MP470; HPK 56 | ||
| Solubility | DMSO : 50 mg/mL (111.73 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| Chemical Name | N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide | ||
| SMILES | C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6 | ||
| Standard InChIKey | FOFDIMHVKGYHRU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. | |||||
| Targets | c-KitD816H | PDGFRαV561D | Flt3D835Y | |||
| IC50 | 10 nM | 40 nM | 81 nM | |||
Amuvatinib (MP-470, HPK 56) Dilution Calculator
Amuvatinib (MP-470, HPK 56) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2346 mL | 11.1729 mL | 22.3459 mL | 44.6917 mL | 55.8647 mL |
| 5 mM | 0.4469 mL | 2.2346 mL | 4.4692 mL | 8.9383 mL | 11.1729 mL |
| 10 mM | 0.2235 mL | 1.1173 mL | 2.2346 mL | 4.4692 mL | 5.5865 mL |
| 50 mM | 0.0447 mL | 0.2235 mL | 0.4469 mL | 0.8938 mL | 1.1173 mL |
| 100 mM | 0.0223 mL | 0.1117 mL | 0.2235 mL | 0.4469 mL | 0.5586 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Amuvatinib (also known as MP-470 or HPK 56), a synthetic carbothioamide, is a novel and potent tyrosine kinase inhibitor, which exerts in vitro and in vivo activities against multiple targets including mutant KIT, platelet-derived growth factor receptor alpha (PDGFRα) and DNA repair. Μechanisticly, amuvatinib inhibits tyrosine kinase receptor KIT through occupying its ATP binding domain (IC50 < 0.1 μM) and disrupts DNA repair through suppression of homologous recombination protein Rad51 as well as synergistic effects in combination with double stranded DNA damaging agents. Recent studies have shown that amuvatinib exhibits antitumor activity against human cancer cell lines, especially GIST-48 human cell line, in which it strongly inhibits proliferation (IC50 = 0.20 μM).
Reference
Raoul Tibes, Gil Fine, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpao Sahai, Mohammad Azab and Anthony W. Tolcher. A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 71: 463-471
Gavin Choy, Rajashree Joshi-Hangal, Aram Oganesian, Gil Fine, Scott Rasmussen, Joanne Collier, James Kissling, Amarpal Sahai, Mohammad Azab and Sanjeev Redkar. Saftety, tolerability, and pharmacokinetics of amuvatinib from three phase 1 clinical studies in healthy volunteers. Cancer Chemother Pharmacol (2012) 70: 183-190
Featured Products
- Danoprevir (RG7227)
Catalog No.:BCC2106
CAS No.:850876-88-9
- Cinchonain IIa
Catalog No.:BCN7716
CAS No.:85081-23-8
- NBI-98782
Catalog No.:BCC4277
CAS No.:85081-18-1
- BX517(PDK1 inhibitor2)
Catalog No.:BCC6391
CAS No.:850717-64-5
- GSK269962A
Catalog No.:BCC5178
CAS No.:850664-21-0
- Alogliptin Benzoate
Catalog No.:BCC1341
CAS No.:850649-62-6
- Alogliptin (SYR-322)
Catalog No.:BCC2113
CAS No.:850649-61-5
- Apigenin 5-O-neohesperidoside
Catalog No.:BCN6840
CAS No.:850630-40-9
- Norviburtinal
Catalog No.:BCN4399
CAS No.:85051-41-8
- Fmoc-Arg(Tos)-ol
Catalog No.:BCC2588
CAS No.:850330-29-9
- Rosin
Catalog No.:BCN5969
CAS No.:85026-55-7
- Cinchonain IIb
Catalog No.:BCN7738
CAS No.:85022-68-0
New Products
- THIP hydrochloride
Catalog No.:BCC6803
CAS No.:85118-33-8
- 2-Methoxystypandrone
Catalog No.:BCN4400
CAS No.:85122-21-0
- PF9 tetrasodium salt
Catalog No.:BCC7854
CAS No.:851265-78-6
- Phospho-Glycogen Synthase Peptide-2 (substrate)
Catalog No.:BCC5747
CAS No.:851366-97-7
- (S)-4-Carboxy-3-hydroxyphenylglycine
Catalog No.:BCC6600
CAS No.:85148-82-9
- Curculigoside C
Catalog No.:BCN3696
CAS No.:851713-74-1
- OC000459
Catalog No.:BCC4507
CAS No.:851723-84-7, 950688-14-9 (sodium salt)
- PF 514273
Catalog No.:BCC7746
CAS No.:851728-60-4
- 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Catalog No.:BCC8587
CAS No.:85175-59-3
- ADX-47273
Catalog No.:BCC4598
CAS No.:851881-60-2
- RuBi-4AP
Catalog No.:BCC6044
CAS No.:851956-02-0
- TOK-001
Catalog No.:BCC3910
CAS No.:851983-85-2
Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity.
Amuvatinib (MP-470, HPK 56),850879-09-3,MP470; HPK 56,Natural Products,c-RET, buy Amuvatinib (MP-470, HPK 56) , Amuvatinib (MP-470, HPK 56) supplier , purchase Amuvatinib (MP-470, HPK 56) , Amuvatinib (MP-470, HPK 56) cost , Amuvatinib (MP-470, HPK 56) manufacturer , order Amuvatinib (MP-470, HPK 56) , high purity Amuvatinib (MP-470, HPK 56)
