NorviburtinalCAS# 85051-41-8 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 85051-41-8 | SDF | Download SDF |
| PubChem ID | 390664 | Appearance | Yellow powder |
| Formula | C9H6O2 | M.Wt | 146.1 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | cyclopenta[c]pyran-7-carbaldehyde | ||
| SMILES | C1=COC=C2C1=CC=C2C=O | ||
| Standard InChIKey | VRMFZTBAWYVGGB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H6O2/c10-5-8-2-1-7-3-4-11-6-9(7)8/h1-6H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Norviburtinal possesses novel angiogenesis effect. 2. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines. 3. Norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity. |
Norviburtinal Dilution Calculator
Norviburtinal Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.8446 mL | 34.2231 mL | 68.4463 mL | 136.8925 mL | 171.1157 mL |
| 5 mM | 1.3689 mL | 6.8446 mL | 13.6893 mL | 27.3785 mL | 34.2231 mL |
| 10 mM | 0.6845 mL | 3.4223 mL | 6.8446 mL | 13.6893 mL | 17.1116 mL |
| 50 mM | 0.1369 mL | 0.6845 mL | 1.3689 mL | 2.7379 mL | 3.4223 mL |
| 100 mM | 0.0684 mL | 0.3422 mL | 0.6845 mL | 1.3689 mL | 1.7112 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Fmoc-Arg(Tos)-ol
Catalog No.:BCC2588
CAS No.:850330-29-9
- Rosin
Catalog No.:BCN5969
CAS No.:85026-55-7
- Cinchonain IIb
Catalog No.:BCN7738
CAS No.:85022-68-0
- Shikonofuran A
Catalog No.:BCN2826
CAS No.:85022-66-8
- ADL5859 HCl
Catalog No.:BCC1265
CAS No.:850173-95-4
- Afatinib dimaleate
Catalog No.:BCC1330
CAS No.:850140-73-7
- Sulfatinib
Catalog No.:BCC8811
CAS No.:1308672-74-3
- 5-Methoxysuberenone
Catalog No.:BCN3638
CAS No.:85011-58-1
- Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate
Catalog No.:BCN7473
CAS No.:85003-85-6
- Altrenogest
Catalog No.:BCC4479
CAS No.:850-52-2
- Sudan III
Catalog No.:BCN6962
CAS No.:85-86-9
- Sudan IV；Solvent Red 24
Catalog No.:BCN8379
CAS No.:85-83-6
- Apigenin 5-O-neohesperidoside
Catalog No.:BCN6840
CAS No.:850630-40-9
- Alogliptin (SYR-322)
Catalog No.:BCC2113
CAS No.:850649-61-5
- Alogliptin Benzoate
Catalog No.:BCC1341
CAS No.:850649-62-6
- GSK269962A
Catalog No.:BCC5178
CAS No.:850664-21-0
- BX517(PDK1 inhibitor2)
Catalog No.:BCC6391
CAS No.:850717-64-5
- NBI-98782
Catalog No.:BCC4277
CAS No.:85081-18-1
- Cinchonain IIa
Catalog No.:BCN7716
CAS No.:85081-23-8
- Danoprevir (RG7227)
Catalog No.:BCC2106
CAS No.:850876-88-9
- Amuvatinib (MP-470, HPK 56)
Catalog No.:BCC2258
CAS No.:850879-09-3
- THIP hydrochloride
Catalog No.:BCC6803
CAS No.:85118-33-8
- 2-Methoxystypandrone
Catalog No.:BCN4400
CAS No.:85122-21-0
- PF9 tetrasodium salt
Catalog No.:BCC7854
CAS No.:851265-78-6
Bioassay-guided isolation of norviburtinal from the root of Rehmannia glutinosa, exhibited angiogenesis effect in zebrafish embryo model.[Pubmed:21843616]
J Ethnopharmacol. 2011 Oct 11;137(3):1323-7.
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Rehmannia glutinosa (RR) is commonly used as a wound-healing agent in various traditional Chinese herbal formulae; while angiogenesis is one of the crucial aspects in wound-healing. AIM OF THE STUDY: The objective of the present study was to investigate the angiogenesis effects of RR aqueous crude extract and its active component(s) using zebrafish model. MATERIALS AND METHODS: The in vivo angiogenesis effect was studied using transgenic TG(fli1:EGFP)(y1)/+(AB) zebrafish embryos by observing the capillary sprouts formation in sub-intestinal vessel (SIV) of zebrafish embryos after 72 h post-fertilization under fluorescence microscopy. RESULTS: Our results indicated that RR aqueous crude extract (250 mug/ml) exhibited significant angiogenesis effect, with an increase in capillary sprouts formation in SIV. Following sequential solvent partition of the RR aqueous crude extract with dichloromethane, ethyl acetate and n-butanol successively, the dichloromethane fraction (DCM) was found to have the most sprouts formation in the SIV region. Subjected to column chromatography, DCM fraction was further fractionated into six sub-fractions and among these tested, the sub-fraction C2 exhibited the most potent angiogenesis effect. The major component, C2A, was isolated and identified as Norviburtinal using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The compound Norviburtinal (at 50 mug/ml) was shown to possess significant angiogenesis effect in zebrafish model (p < 0.001). CONCLUSIONS: Norviburtinal was, for the first time, found in the extract of RR and possessed novel angiogenesis effect. Bioassay-guided fractionation suggested that Norviburtinal was not the only active component responsible for the angiogenesis effect of RR.
In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines.[Pubmed:11199138]
Planta Med. 2000 Dec;66(8):758-61.
Crude dichloromethane extracts of Kigelia pinnata stem bark and fruit showed cytotoxic activity in vitro against cultured melanoma and other cancer cell lines using the Sulphorhodamine B assay, which was used for bioassay-guided fractionation. Thin layer chromatography (TLC) examination of the most active fractions of both stem bark and fruits showed the presence of the same major components which were found to be Norviburtinal and beta-sitosterol. Norviburtinal was found to be the most active compound but had little selectivity for melanoma cell lines whilst isopinnatal also showed some cytotoxic activity. beta-Sitosterol was found to be comparatively inactive. HPLC analysis of the crude extract showed that the amount of Norviburtinal present in the plant material did not account for all of the activity of the total extracts.
