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Neoprzewaquinone A

CAS# 630057-39-5

Neoprzewaquinone A

Catalog No. BCN4169----Order now to get a substantial discount!

Product Name & Size Price Stock
Neoprzewaquinone A: 5mg $322 In Stock
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Quality Control of Neoprzewaquinone A

Number of papers citing our products

Chemical structure

Neoprzewaquinone A

3D structure

Chemical Properties of Neoprzewaquinone A

Cas No. 630057-39-5 SDF Download SDF
PubChem ID 124222343 Appearance Red powder
Formula C36H28O6 M.Wt 556.6
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2Z)-2,11,28-trimethyl-19-methylidene-13,30-dioxaheptacyclo[21.11.0.06,18.07,15.010,14.024,32.027,31]tetratriaconta-1(23),2,6(18),7(15),10(14),11,16,24(32),27(31),28,33-undecaene-8,9,25,26-tetrone
SMILES CC1=CCCC2=C(C=CC3=C2C(=O)C(=O)C4=C3OC=C4C)C(=C)CCCC5=C1C=CC6=C5C(=O)C(=O)C7=C6OC=C7C
Standard InChIKey SXQCYGZVSVUMEL-LSCVHKIXSA-N
Standard InChI InChI=1S/C36H28O6/c1-17-7-5-9-24-22(12-14-26-30(24)34(40)32(38)28-20(4)16-42-36(26)28)18(2)8-6-10-23-21(17)11-13-25-29(23)33(39)31(37)27-19(3)15-41-35(25)27/h8,11-16H,1,5-7,9-10H2,2-4H3/b18-8-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neoprzewaquinone A

The roots of Salvia miltiorrhiza

Biological Activity of Neoprzewaquinone A

DescriptionNeoprzewaquinone A has algicidal effect on M. aeruginosa , with EC50 of 4.68 mg /L, the potential inhibition mechanisms are neo-przewaquinone A caused M. aeruginosa cells morphologic damage or lysis.
TargetsAntifection
In vitro

Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism.[Pubmed: 23810520]

Chemosphere. 2013 Oct;93(6):997-1004.

The present study was to isolate and identify a potent algicidal compound from extract of Salvia miltiorrhiza and study the potential inhibition mechanism on Microcystis aeruginosa.
METHODS AND RESULTS:
Column chromatography and bioassay-guided fractionation methods were carried out to yield neo-przewaquinone A, which was identified by spectral analysis. The EC50 of Neoprzewaquinone A on M. aeruginosa were 4.68 mg L(-1). In addition, neo-przewaquinone A showed relatively higher security on Chlorella pyrenoidosa and Scenedesmus obliquus, with the EC50 values of 14.78 and 10.37 mg L(-1), respectively. For the potential inhibition mechanisms, Neoprzewaquinone A caused M. aeruginosa cells morphologic damage or lysis, increased malondialdehyde content and decreased the soluble protein content, total antioxidant and superoxide dismutase activity, and significantly inhibited three photosynthesis-related genes (psaB, psbD, and rbcL).
CONCLUSIONS:
The results demonstrated the algicidal effect of Neoprzewaquinone A on M. aeruginosa and provided the possible inhibition mechanisms.

Protocol of Neoprzewaquinone A

Structure Identification
Yao Xue Xue Bao. 2003 May;38(5):354-7.

Chemical constituents in the roots of Salvia przewalskii Maxim.[Pubmed: 12958839]

To investigate the chemical composition of the root of Salvia przewalskii Maxim.
METHODS AND RESULTS:
Compounds were isolated by silica gel column chromatography. Structures of these compounds were elucidated by spectral analysis (EI-MS, FAB-MS, 1HNMR, 13CNMR, 1H-1H COSY, 1H-13C COSY, HMBC, NOESY) and phytochemical properties. Eight compounds were isolated and identified as: tanshinone II-A (I), crypotanshinone (II), przewaquinone A (III), sugiol (IV), ursolic acid (V), 2 alpha, 3 alpha-dihydroxy urs-12-ene-28-acid (VI), oleanolic acid (VII), and Neoprzewaquinone A (VIII).
CONCLUSIONS:
Compound VIII is a new compound, and compound II, IV, V, VI and VII are isolated from this plant for the first time.

Neoprzewaquinone A Dilution Calculator

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Neoprzewaquinone A Molarity Calculator

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Preparing Stock Solutions of Neoprzewaquinone A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7966 mL 8.9831 mL 17.9662 mL 35.9324 mL 44.9156 mL
5 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
10 mM 0.1797 mL 0.8983 mL 1.7966 mL 3.5932 mL 4.4916 mL
50 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3593 mL 0.4492 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neoprzewaquinone A

[Chemical constituents in the roots of Salvia przewalskii Maxim].[Pubmed:12958839]

Yao Xue Xue Bao. 2003 May;38(5):354-7.

AIM: To investigate the chemical composition of the root of Salvia przewalskii Maxim. METHODS: Compounds were isolated by silica gel column chromatography. Structures of these compounds were elucidated by spectral analysis (EI-MS, FAB-MS, 1HNMR, 13CNMR, 1H-1H COSY, 1H-13C COSY, HMBC, NOESY) and phytochemical properties. RESULTS: Eight compounds were isolated and identified as: tanshinone II-A (I), crypotanshinone (II), przewaquinone A (III), sugiol (IV), ursolic acid (V), 2 alpha, 3 alpha-dihydroxy urs-12-ene-28-acid (VI), oleanolic acid (VII), and neo-przewaquinone A (VIII). CONCLUSION: Compound VIII is a new compound, and compound II, IV, V, VI and VII are isolated from this plant for the first time.

Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism.[Pubmed:23810520]

Chemosphere. 2013 Oct;93(6):997-1004.

The present study was to isolate and identify a potent algicidal compound from extract of Salvia miltiorrhiza and study the potential inhibition mechanism on Microcystis aeruginosa. Column chromatography and bioassay-guided fractionation methods were carried out to yield neo-przewaquinone A, which was identified by spectral analysis. The EC50 of neo-przewaquinone A on M. aeruginosa were 4.68 mg L(-1). In addition, neo-przewaquinone A showed relatively higher security on Chlorella pyrenoidosa and Scenedesmus obliquus, with the EC50 values of 14.78 and 10.37 mg L(-1), respectively. For the potential inhibition mechanisms, neo-przewaquinone A caused M. aeruginosa cells morphologic damage or lysis, increased malondialdehyde content and decreased the soluble protein content, total antioxidant and superoxide dismutase activity, and significantly inhibited three photosynthesis-related genes (psaB, psbD, and rbcL). The results demonstrated the algicidal effect of neo-przewaquinone A on M. aeruginosa and provided the possible inhibition mechanisms.

Description

Neoprzewaquinone A is isolated from the roots of Salvia miltiorrhiza.

Keywords:

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