6-AminoquinoxalineCAS# 6298-37-9 |
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| Cas No. | 6298-37-9 | SDF | Download SDF |
| PubChem ID | 237859 | Appearance | Powder |
| Formula | C8H7N3 | M.Wt | 145 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | quinoxalin-6-amine | ||
| SMILES | C1=CC2=NC=CN=C2C=C1N | ||
| Standard InChIKey | MSGRFBKVMUKEGZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H7N3/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,9H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
6-Aminoquinoxaline Dilution Calculator
6-Aminoquinoxaline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.8966 mL | 34.4828 mL | 68.9655 mL | 137.931 mL | 172.4138 mL |
| 5 mM | 1.3793 mL | 6.8966 mL | 13.7931 mL | 27.5862 mL | 34.4828 mL |
| 10 mM | 0.6897 mL | 3.4483 mL | 6.8966 mL | 13.7931 mL | 17.2414 mL |
| 50 mM | 0.1379 mL | 0.6897 mL | 1.3793 mL | 2.7586 mL | 3.4483 mL |
| 100 mM | 0.069 mL | 0.3448 mL | 0.6897 mL | 1.3793 mL | 1.7241 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New 6-Aminoquinoxaline Derivatives with Neuroprotective Effect on Dopaminergic Neurons in Cellular and Animal Parkinson Disease Models.[Pubmed:27341519]
J Med Chem. 2016 Jul 14;59(13):6169-86.
Parkinson's disease (PD) is a neurodegenerative disorder of aging characterized by motor symptoms that result from the loss of midbrain dopamine neurons and the disruption of dopamine-mediated neurotransmission. There is currently no curative treatment for this disorder. To discover druggable neuroprotective compounds for dopamine neurons, we have designed and synthesized a second-generation of quinoxaline-derived molecules based on structure-activity relationship studies, which led previously to the discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c). Neuroprotection assessment in PD cellular models of our newly synthesized quinoxaline-derived compounds has led to the selection of a better hit compound, PAQ (4c). Extensive in vitro characterization of 4c showed that its neuroprotective action is partially attributable to the activation of reticulum endoplasmic ryanodine receptor channels. Most interestingly, 4c was able to attenuate neurodegeneration in a mouse model of PD, making this compound an interesting drug candidate for the treatment of this disorder.
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