H-Met-OHCAS# 63-68-3 |
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| Cas No. | 63-68-3 | SDF | Download SDF |
| PubChem ID | 6137 | Appearance | White powder |
| Formula | C5H11NO2S | M.Wt | 149.2 |
| Type of Compound | Nitrogen-containing Compounds | Storage | Desiccate at -20°C |
| Synonyms | L-methionine; 63-68-3; Methionine | ||
| Solubility | H2O : 16.67 mg/mL (111.72 mM; Need ultrasonic) | ||
| Chemical Name | (2S)-2-amino-4-methylsulfanylbutanoic acid | ||
| SMILES | CSCCC(C(=O)O)N | ||
| Standard InChIKey | FFEARJCKVFRZRR-BYPYZUCNSA-N | ||
| Standard InChI | InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
H-Met-OH Dilution Calculator
H-Met-OH Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.7024 mL | 33.5121 mL | 67.0241 mL | 134.0483 mL | 167.5603 mL |
| 5 mM | 1.3405 mL | 6.7024 mL | 13.4048 mL | 26.8097 mL | 33.5121 mL |
| 10 mM | 0.6702 mL | 3.3512 mL | 6.7024 mL | 13.4048 mL | 16.756 mL |
| 50 mM | 0.134 mL | 0.6702 mL | 1.3405 mL | 2.681 mL | 3.3512 mL |
| 100 mM | 0.067 mL | 0.3351 mL | 0.6702 mL | 1.3405 mL | 1.6756 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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H-Met-OH
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Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.[Pubmed:10691692]
J Med Chem. 2000 Feb 24;43(4):664-74.
The cholecystokinin-8 (CCK-8)-inactivating peptidase is a serine peptidase which has been shown to be a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10). It cleaves the neurotransmitter CCK-8 sulfate at the Met-Gly bond to give Asp-Tyr(SO(3)H)-Met-OH + Gly-Trp-Met-Asp-Phe-NH(2). In seeking a reversible inhibitor of this peptidase, the enzymatic binding subsites were characterized using a fluorimetric assay based on the hydrolysis of the artificial substrate Ala-Ala-Phe-amidomethylcoumarin. A series of di- and tripeptides having various alkyl or aryl side chains was studied to determine the accessible volume for binding and to probe the potential for hydrophobic interactions. From this initial study the tripeptides Ile-Pro-Ile-OH (K(i) = 1 microM) and Ala-Pro-Ala-OH (K(i) = 3 microM) and dipeptide amide Val-Nvl-NHBu (K(i) = 3 microM) emerged as leads. Comparison of these structures led to the synthesis of Val-Pro-NHBu (K(i) = 0.57 microM) which served for later optimization in the design of butabindide, a potent reversible competitive and selective inhibitor of the CCK-8-inactivating peptidase. The strategy for this work is explicitly described since it illustrates a possible general approach for peptidase inhibitor design.
L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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