H-Met-OH

CAS# 63-68-3

H-Met-OH

Catalog No. BCC2993----Order now to get a substantial discount!

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Chemical structure

H-Met-OH

3D structure

Chemical Properties of H-Met-OH

Cas No. 63-68-3 SDF Download SDF
PubChem ID 6137 Appearance White powder
Formula C5H11NO2S M.Wt 149.2
Type of Compound Nitrogen-containing Compounds Storage Desiccate at -20°C
Synonyms L-methionine; 63-68-3; Methionine
Solubility H2O : 16.67 mg/mL (111.72 mM; Need ultrasonic)
Chemical Name (2S)-2-amino-4-methylsulfanylbutanoic acid
SMILES CSCCC(C(=O)O)N
Standard InChIKey FFEARJCKVFRZRR-BYPYZUCNSA-N
Standard InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

H-Met-OH Dilution Calculator

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H-Met-OH Molarity Calculator

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Preparing Stock Solutions of H-Met-OH

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.7024 mL 33.5121 mL 67.0241 mL 134.0483 mL 167.5603 mL
5 mM 1.3405 mL 6.7024 mL 13.4048 mL 26.8097 mL 33.5121 mL
10 mM 0.6702 mL 3.3512 mL 6.7024 mL 13.4048 mL 16.756 mL
50 mM 0.134 mL 0.6702 mL 1.3405 mL 2.681 mL 3.3512 mL
100 mM 0.067 mL 0.3351 mL 0.6702 mL 1.3405 mL 1.6756 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on H-Met-OH

Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.[Pubmed:10691692]

J Med Chem. 2000 Feb 24;43(4):664-74.

The cholecystokinin-8 (CCK-8)-inactivating peptidase is a serine peptidase which has been shown to be a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10). It cleaves the neurotransmitter CCK-8 sulfate at the Met-Gly bond to give Asp-Tyr(SO(3)H)-Met-OH + Gly-Trp-Met-Asp-Phe-NH(2). In seeking a reversible inhibitor of this peptidase, the enzymatic binding subsites were characterized using a fluorimetric assay based on the hydrolysis of the artificial substrate Ala-Ala-Phe-amidomethylcoumarin. A series of di- and tripeptides having various alkyl or aryl side chains was studied to determine the accessible volume for binding and to probe the potential for hydrophobic interactions. From this initial study the tripeptides Ile-Pro-Ile-OH (K(i) = 1 microM) and Ala-Pro-Ala-OH (K(i) = 3 microM) and dipeptide amide Val-Nvl-NHBu (K(i) = 3 microM) emerged as leads. Comparison of these structures led to the synthesis of Val-Pro-NHBu (K(i) = 0.57 microM) which served for later optimization in the design of butabindide, a potent reversible competitive and selective inhibitor of the CCK-8-inactivating peptidase. The strategy for this work is explicitly described since it illustrates a possible general approach for peptidase inhibitor design.

Description

L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

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