NeostenineCAS# 477953-07-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 477953-07-4 | SDF | Download SDF |
| PubChem ID | 11536426 | Appearance | Powder |
| Formula | C17H27NO2 | M.Wt | 277.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1S,9R,10R,11R,14S,15R,16R)-10-ethyl-14-methyl-12-oxa-4-azatetracyclo[7.6.1.04,16.011,15]hexadecan-13-one | ||
| SMILES | CCC1C2CCCCN3C2C(CC3)C4C1OC(=O)C4C | ||
| Standard InChIKey | ROIHYOJMCBKEER-FGBMJVKNSA-N | ||
| Standard InChI | InChI=1S/C17H27NO2/c1-3-11-12-6-4-5-8-18-9-7-13(15(12)18)14-10(2)17(19)20-16(11)14/h10-16H,3-9H2,1-2H3/t10-,11+,12+,13-,14-,15+,16+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Stemona sessilifolia
| Description | 1. Neostenine shows significant antitussive activities. |
Neostenine Dilution Calculator
Neostenine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6049 mL | 18.0245 mL | 36.049 mL | 72.0981 mL | 90.1226 mL |
| 5 mM | 0.721 mL | 3.6049 mL | 7.2098 mL | 14.4196 mL | 18.0245 mL |
| 10 mM | 0.3605 mL | 1.8025 mL | 3.6049 mL | 7.2098 mL | 9.0123 mL |
| 50 mM | 0.0721 mL | 0.3605 mL | 0.721 mL | 1.442 mL | 1.8025 mL |
| 100 mM | 0.036 mL | 0.1802 mL | 0.3605 mL | 0.721 mL | 0.9012 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation, characterization and acetylcholinesterase inhibitory activity of alkaloids from roots of Stemona sessilifolia.[Pubmed:23831460]
Fitoterapia. 2013 Sep;89:257-64.
Two new alkaloids, named stenine A (1) and stenine B (2), along with the known compounds Neostenine (3), stenine (4) and neotuberostemonine (5), were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1D- and 2D-NMR spectra and X-ray single-crystal diffraction experiment. Anti-acetylcholinesterase (AChE) activity of compounds 1-5 were also tested. Compounds 2 and 4 showed significant anti-acetylcholinesterase activities, with IC50 values of 2.1+/-0.2 muM and 19.8+/-2.5 muM, resp. The mode of AChE inhibition by Compound 2 (the most potential AChE inhibitor) was reversible and competitive. In addition, molecular modeling was performed to explore the binding mode of compound 2 with AChE.
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