Neostenine

CAS# 477953-07-4

Neostenine

Catalog No. BCN5541----Order now to get a substantial discount!

Product Name & Size Price Stock
Neostenine: 5mg $989 In Stock
Neostenine: 10mg Please Inquire In Stock
Neostenine: 20mg Please Inquire Please Inquire
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Quality Control of Neostenine

Number of papers citing our products

Chemical structure

Neostenine

3D structure

Chemical Properties of Neostenine

Cas No. 477953-07-4 SDF Download SDF
PubChem ID 11536426 Appearance Powder
Formula C17H27NO2 M.Wt 277.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,9R,10R,11R,14S,15R,16R)-10-ethyl-14-methyl-12-oxa-4-azatetracyclo[7.6.1.04,16.011,15]hexadecan-13-one
SMILES CCC1C2CCCCN3C2C(CC3)C4C1OC(=O)C4C
Standard InChIKey ROIHYOJMCBKEER-FGBMJVKNSA-N
Standard InChI InChI=1S/C17H27NO2/c1-3-11-12-6-4-5-8-18-9-7-13(15(12)18)14-10(2)17(19)20-16(11)14/h10-16H,3-9H2,1-2H3/t10-,11+,12+,13-,14-,15+,16+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neostenine

The roots of Stemona sessilifolia

Biological Activity of Neostenine

Description1. Neostenine shows significant antitussive activities.

Neostenine Dilution Calculator

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Neostenine Molarity Calculator

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Preparing Stock Solutions of Neostenine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6049 mL 18.0245 mL 36.049 mL 72.0981 mL 90.1226 mL
5 mM 0.721 mL 3.6049 mL 7.2098 mL 14.4196 mL 18.0245 mL
10 mM 0.3605 mL 1.8025 mL 3.6049 mL 7.2098 mL 9.0123 mL
50 mM 0.0721 mL 0.3605 mL 0.721 mL 1.442 mL 1.8025 mL
100 mM 0.036 mL 0.1802 mL 0.3605 mL 0.721 mL 0.9012 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neostenine

Isolation, characterization and acetylcholinesterase inhibitory activity of alkaloids from roots of Stemona sessilifolia.[Pubmed:23831460]

Fitoterapia. 2013 Sep;89:257-64.

Two new alkaloids, named stenine A (1) and stenine B (2), along with the known compounds Neostenine (3), stenine (4) and neotuberostemonine (5), were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1D- and 2D-NMR spectra and X-ray single-crystal diffraction experiment. Anti-acetylcholinesterase (AChE) activity of compounds 1-5 were also tested. Compounds 2 and 4 showed significant anti-acetylcholinesterase activities, with IC50 values of 2.1+/-0.2 muM and 19.8+/-2.5 muM, resp. The mode of AChE inhibition by Compound 2 (the most potential AChE inhibitor) was reversible and competitive. In addition, molecular modeling was performed to explore the binding mode of compound 2 with AChE.

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