Droserone

CAS# 478-40-0

Droserone

Catalog No. BCN7985----Order now to get a substantial discount!

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Quality Control of Droserone

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Chemical structure

Droserone

3D structure

Chemical Properties of Droserone

Cas No. 478-40-0 SDF Download SDF
PubChem ID 442739 Appearance Powder
Formula C11H8O4 M.Wt 204.18
Type of Compound Quinones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4,8-dihydroxy-3-methylnaphthalene-1,2-dione
SMILES CC1=C(C2=C(C(=CC=C2)O)C(=O)C1=O)O
Standard InChIKey KILMMLMKSQWMTN-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H8O4/c1-5-9(13)6-3-2-4-7(12)8(6)11(15)10(5)14/h2-4,12-13H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Droserone

The herbs of Plumbago zeylanica

Biological Activity of Droserone

Description1. Droserone inhibits in vitro measles virus infection. 2. Droserone exerts an antifungal effect on a wide range of plant and human fungal pathogens.
TargetsAntifection

Droserone Dilution Calculator

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Droserone Molarity Calculator

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Preparing Stock Solutions of Droserone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8976 mL 24.4882 mL 48.9764 mL 97.9528 mL 122.441 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL 19.5906 mL 24.4882 mL
10 mM 0.4898 mL 2.4488 mL 4.8976 mL 9.7953 mL 12.2441 mL
50 mM 0.098 mL 0.4898 mL 0.9795 mL 1.9591 mL 2.4488 mL
100 mM 0.049 mL 0.2449 mL 0.4898 mL 0.9795 mL 1.2244 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Droserone

Induced production of antifungal naphthoquinones in the pitchers of the carnivorous plant Nepenthes khasiana.[Pubmed:20018905]

J Exp Bot. 2010 Mar;61(3):911-22.

Nepenthes spp. are carnivorous plants that have developed insect capturing traps, evolved by specific modification of the leaf tips, and are able to utilize insect degradation products as nutritional precursors. A chitin-induced antifungal ability, based on the production and secretion to the trap liquid of Droserone and 5-O-methylDroserone, is described here. Such specific secretion uniquely occurred when chitin injection was used as the eliciting agent and probably reflects a certain kind of defence mechanism that has been evolved for protecting the carnivory-based provision of nutritional precursors. The pitcher liquid containing Droserone and 5-O-methylDroserone at 3:1 or 4:1 molar ratio, as well as the purified naphthoquinones, exerted an antifungal effect on a wide range of plant and human fungal pathogens. When tested against Candida and Aspergillus spp., the concentrations required for achieving inhibitory and fungicidal effects were significantly lower than those causing cytotoxicity in cells of the human embryonic kidney cell line, 293T. These naturally secreted 1,4-naphthoquinone derivatives, that are assumed to act via semiquinone enhancement of free radical production, may offer a new lead to develop alternative antifungal drugs with reduced selectable pressure for potentially evolved resistance.

The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.[Pubmed:27420351]

Planta Med. 2017 Feb;83(3-04):232-238.

The naphthoquinone Droserone (1) is a natural product occurring in dicotyledonous plants. We have now observed that the addition of 1 during infection of tissue culture cells with measles virus considerably reduced the infection. Interestingly, the infection was inhibited only when Droserone (1) was added during virus entry, but not when added to the cells prior to virus uptake or after virus uptake. These findings suggest that 1 interacts with viral particles to reduce infectivity. The formation of progeny measles virus particles was inhibited to 50 % by Droserone (1) at a concentration (IC50) of approximately 2 microM with a half-maximal cytotoxicity (CC50) of about 60 microM for Vero cells. Other tested naphthoquinone derivatives, among them the likewise natural plumbagin (2), but also synthetic analogs, were either more cytotoxic or not as effective as 1. Thus, our data do not support the development of naphthoquinone derivatives into antiviral compounds, but suggest that they may be interesting research tools to study measles virus entry into cells.

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