NeuropathiazolSelective inducer of neuronal differentiation in hippocampal neural progenitors CAS# 880090-88-0 |
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| Cas No. | 880090-88-0 | SDF | Download SDF |
| PubChem ID | 11667240 | Appearance | Powder |
| Formula | C19H18N2O2S | M.Wt | 338.42 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 33.33 mg/mL (98.49 mM; Need ultrasonic) | ||
| Chemical Name | ethyl 4-[methyl-(2-phenyl-1,3-thiazol-4-yl)amino]benzoate | ||
| SMILES | CCOC(=O)C1=CC=C(C=C1)N(C)C2=CSC(=N2)C3=CC=CC=C3 | ||
| Standard InChIKey | MGKYEWWFHSESJN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H18N2O2S/c1-3-23-19(22)15-9-11-16(12-10-15)21(2)17-13-24-18(20-17)14-7-5-4-6-8-14/h4-13H,3H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective inducer of neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs). Selectively suppresses astrocyte differentiation when induced by LIF, BMP2 and FBS compared to retinoic acid. Enhances maturation of NPC derived neurons. |
Neuropathiazol Dilution Calculator
Neuropathiazol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9549 mL | 14.7745 mL | 29.5491 mL | 59.0982 mL | 73.8727 mL |
| 5 mM | 0.591 mL | 2.9549 mL | 5.9098 mL | 11.8196 mL | 14.7745 mL |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9549 mL | 5.9098 mL | 7.3873 mL |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.591 mL | 1.182 mL | 1.4775 mL |
| 100 mM | 0.0295 mL | 0.1477 mL | 0.2955 mL | 0.591 mL | 0.7387 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Neuropathiazol is a synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells.
References:
[1]. Warashina M, et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16;45(4):591-3.
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High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture.[Pubmed:30229860]
Biotechnol Bioeng. 2019 Jan;116(1):168-180.
Identification of conditions for guided and specific differentiation of human stem cell and progenitor cells is important for continued development and engineering of in vitro cell culture systems for use in regenerative medicine, drug discovery, and human toxicology. Three-dimensional (3D) and organotypic cell culture models have been used increasingly for in vitro cell culture because they may better model endogenous tissue environments. However, detailed studies of stem cell differentiation within 3D cultures remain limited, particularly with respect to high-throughput screening. Herein, we demonstrate the use of a microarray chip-based platform to screen, in high-throughput, individual and paired effects of 12 soluble factors on the neuronal differentiation of a human neural progenitor cell line (ReNcell VM) encapsulated in microscale 3D Matrigel cultures. Dose-response analysis of selected combinations from the initial combinatorial screen revealed that the combined treatment of all-trans retinoic acid (RA) with the glycogen synthase kinase 3 inhibitor CHIR-99021 (CHIR) enhances neurogenesis while simultaneously decreases astrocyte differentiation, whereas the combined treatment of brain-derived neurotrophic factor and the small azide Neuropathiazol enhances the differentiation into neurons and astrocytes. Subtype specification analysis of RA- and CHIR-differentiated cultures revealed that enhanced neurogenesis was not biased toward a specific neuronal subtype. Together, these results demonstrate a high-throughput screening platform for rapid evaluation of differentiation conditions in a 3D environment, which will aid the development and application of 3D stem cell culture models.
