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Notoginsenoside Fa

CAS# 88100-04-3

Notoginsenoside Fa

Catalog No. BCN3854----Order now to get a substantial discount!

Product Name & Size Price Stock
Notoginsenoside Fa: 5mg $63 In Stock
Notoginsenoside Fa: 10mg Please Inquire In Stock
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Quality Control of Notoginsenoside Fa

Number of papers citing our products

Chemical structure

Notoginsenoside Fa

3D structure

Chemical Properties of Notoginsenoside Fa

Cas No. 88100-04-3 SDF Download SDF
PubChem ID 44592853 Appearance White powder
Formula C59H100O27 M.Wt 1241.4
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in methanol; insoluble in water
Chemical Name (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)OC7C(C(C(CO7)O)O)O)C)C)O)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C
Standard InChIKey HERICYNRBVMDFO-WVYXDZFESA-N
Standard InChI InChI=1S/C59H100O27/c1-24(2)10-9-14-59(8,86-52-47(76)42(71)40(69)31(82-52)23-78-50-46(75)41(70)37(66)28(19-60)79-50)25-11-16-58(7)35(25)26(63)18-33-56(5)15-13-34(55(3,4)32(56)12-17-57(33,58)6)83-53-48(43(72)38(67)29(20-61)80-53)85-54-49(44(73)39(68)30(21-62)81-54)84-51-45(74)36(65)27(64)22-77-51/h10,25-54,60-76H,9,11-23H2,1-8H3/t25-,26+,27+,28+,29+,30+,31+,32-,33+,34-,35-,36-,37+,38+,39+,40+,41-,42-,43-,44-,45+,46+,47+,48+,49+,50+,51-,52-,53-,54-,56-,57+,58+,59-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Notoginsenoside Fa

The roots of Panax notoginseng

Biological Activity of Notoginsenoside Fa

DescriptionNotoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.
In vitro

Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.[Pubmed: 12350149]

J. Nat. Prod., 2002, 65(9):1288-92.


METHODS AND RESULTS:
Four new dammarane-type saponins (1-4), named yesanchinosides G-J, together with nine ginsenosides (5-13) were isolated from Ye-Sanchi, the underground part of Panax japonicus collected in the south of Yunnan Province, China. Their structures were elucidated on the basis of spectroscopic and chemical methods.
CONCLUSIONS:
Ginsenosides Rb(1) and Rb(3) and notoginsenosides R(4) (6) and Notoginsenoside Fa (7) showed significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.

Notoginsenoside Fa Dilution Calculator

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Notoginsenoside Fa Molarity Calculator

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Preparing Stock Solutions of Notoginsenoside Fa

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.8055 mL 4.0277 mL 8.0554 mL 16.1108 mL 20.1386 mL
5 mM 0.1611 mL 0.8055 mL 1.6111 mL 3.2222 mL 4.0277 mL
10 mM 0.0806 mL 0.4028 mL 0.8055 mL 1.6111 mL 2.0139 mL
50 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.3222 mL 0.4028 mL
100 mM 0.0081 mL 0.0403 mL 0.0806 mL 0.1611 mL 0.2014 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Notoginsenoside Fa

Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells.[Pubmed:12350149]

J Nat Prod. 2002 Sep;65(9):1288-92.

Four new dammarane-type saponins (1-4), named yesanchinosides G-J, together with nine ginsenosides (5-13) were isolated from Ye-Sanchi, the underground part of Panax japonicus collected in the south of Yunnan Province, China. Their structures were elucidated on the basis of spectroscopic and chemical methods. Ginsenosides Rb(1) and Rb(3) and notoginsenosides R(4) (6) and Fa (7) showed significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells.

Description

Notoginsenoside Fa, a protopanaxadiol (ppd)-type saponin isolated from P. notoginseng, could possibly activate and recover the function of degenerated brain.

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