Notoginsenoside FcCAS# 88122-52-5 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 88122-52-5 | SDF | Download SDF |
| PubChem ID | 75412556 | Appearance | Powder |
| Formula | C58H98O26 | M.Wt | 1211.4 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol | ||
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)OC7C(C(C(CO7)O)O)O)C)C)O)C)OC8C(C(C(C(O8)COC9C(C(C(CO9)O)O)O)O)O)O)C | ||
| Standard InChIKey | XBGLCVZQMWKHFC-NMQALWILSA-N | ||
| Standard InChI | InChI=1S/C58H98O26/c1-24(2)10-9-14-58(8,84-51-46(74)41(69)40(68)31(80-51)23-77-49-44(72)36(64)27(62)21-75-49)25-11-16-57(7)35(25)26(61)18-33-55(5)15-13-34(54(3,4)32(55)12-17-56(33,57)6)81-52-47(42(70)38(66)29(19-59)78-52)83-53-48(43(71)39(67)30(20-60)79-53)82-50-45(73)37(65)28(63)22-76-50/h10,25-53,59-74H,9,11-23H2,1-8H3/t25-,26+,27+,28+,29+,30+,31+,32-,33+,34-,35-,36-,37-,38+,39+,40+,41-,42-,43-,44+,45+,46+,47+,48+,49-,50-,51-,52-,53-,55-,56+,57+,58-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Notoginsenoside Fc has perfect anti-platelet aggregatory effect. |
| Targets | PAFR |
| In vivo | Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]J Pharm Biomed Anal. 2015 May 10;109:150-7.Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown. |
| Structure Identification | Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl.Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue).[Pubmed: 1294178]Six saponins were isolated from the fruit pedicels of Panax notoginseng. |
Notoginsenoside Fc Dilution Calculator
Notoginsenoside Fc Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.8255 mL | 4.1275 mL | 8.2549 mL | 16.5098 mL | 20.6373 mL |
| 5 mM | 0.1651 mL | 0.8255 mL | 1.651 mL | 3.302 mL | 4.1275 mL |
| 10 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 1.651 mL | 2.0637 mL |
| 50 mM | 0.0165 mL | 0.0825 mL | 0.1651 mL | 0.3302 mL | 0.4127 mL |
| 100 mM | 0.0083 mL | 0.0413 mL | 0.0825 mL | 0.1651 mL | 0.2064 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- JNJ-26854165 (Serdemetan)
Catalog No.:BCC2240
CAS No.:881202-45-5
- Valganciclovir
Catalog No.:BCC2026
CAS No.:88110-89-8
- Notoginsenoside Fe
Catalog No.:BCN3852
CAS No.:88105-29-7
- 30-Hydroxygambogic acid
Catalog No.:BCN3081
CAS No.:881027-36-7
- HDS 029
Catalog No.:BCC7441
CAS No.:881001-19-0
- Notoginsenoside Fa
Catalog No.:BCN3854
CAS No.:88100-04-3
- Phrixotoxin 3
Catalog No.:BCC6328
CAS No.:880886-00-0
- 4-Hydroxybenzaldehyde rhamnoside
Catalog No.:BCN7625
CAS No.:88086-86-6
- PhiKan 083
Catalog No.:BCC2411
CAS No.:880813-36-5
- Naloxonazine dihydrochloride
Catalog No.:BCC6710
CAS No.:880759-65-9
- AMD-070 hydrochloride
Catalog No.:BCC1358
CAS No.:880549-30-4
- Fmoc-Hyp-OH
Catalog No.:BCC3254
CAS No.:88050-17-3
- KU-0060648
Catalog No.:BCC1110
CAS No.:881375-00-4
- Daphniyunnine A
Catalog No.:BCN4428
CAS No.:881388-87-0
- Daphniyunnine B
Catalog No.:BCN4429
CAS No.:881388-88-1
- 6-Formyllimetin
Catalog No.:BCN3427
CAS No.:88140-31-2
- Dauriporphine
Catalog No.:BCN7903
CAS No.:88142-60-3
- DuP 697
Catalog No.:BCC7064
CAS No.:88149-94-4
- Amlodipine
Catalog No.:BCC4396
CAS No.:88150-42-9
- G-1
Catalog No.:BCC6045
CAS No.:881639-98-1
- 26RFa
Catalog No.:BCC6163
CAS No.:881640-56-8
- Levistilide A
Catalog No.:BCN1197
CAS No.:88182-33-6
- 3,5,9-Trihydroxyergosta-7,22-dien-6-one
Catalog No.:BCN1318
CAS No.:88191-14-4
- MDL 28170
Catalog No.:BCC2352
CAS No.:88191-84-8
Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed:25770412]
J Pharm Biomed Anal. 2015 May 10;109:150-7.
Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown. In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56-->m/z 783.90 and m/z 799.93-->m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002mug/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits. The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
[Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue)].[Pubmed:1294178]
Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl..
Six saponins were isolated from the fruit pedicels of Panax notoginseng. Five of them were identified as gypenoside-XVII, -XV, ginsenoside-Rb1, and notoginsenoside-Fc, -Fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards. Quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry.
