Gypenoside XIII

CAS# 80325-22-0

Gypenoside XIII

2D Structure

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Gypenoside XIII

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Chemical Properties of Gypenoside XIII

Cas No. 80325-22-0 SDF Download SDF
PubChem ID 11331683 Appearance Powder
Formula C41H70O12 M.Wt 755.0
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol
SMILES CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)O)C)C)O)C)OC5C(C(C(C(O5)COC6C(C(C(CO6)O)O)O)O)O)O)C
Standard InChIKey YNBYFOIDLBTOMW-IPTBNLQOSA-N
Standard InChI InChI=1S/C41H70O12/c1-21(2)10-9-14-41(8,53-36-34(49)32(47)31(46)25(52-36)20-51-35-33(48)30(45)24(43)19-50-35)22-11-16-40(7)29(22)23(42)18-27-38(5)15-13-28(44)37(3,4)26(38)12-17-39(27,40)6/h10,22-36,42-49H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30-,31+,32-,33+,34+,35-,36-,38-,39+,40+,41-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Gypenoside XIII

The roots of Panax notoginseng (Burk.) F.H.Chen

Biological Activity of Gypenoside XIII

DescriptionGypenoside XIII is belonging to the gypenosides. Gypenosides, found in Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis. References: Yang K, et al. Gypenoside XVII Prevents Atherosclerosis by Attenuating Endothelial Apoptosis and Oxidative Stress: Insight into the ERα-Mediated PI3K/Akt Pathway. Int J Mol Sci. 2017 Feb 9;18(2).

Protocol of Gypenoside XIII

Structure Identification
Natural product research and development, 2006, 18:549-554.

A Further Investigation on the Chemical Constituents from the Leaves of Panax notoginseng.[Reference: WebLink]


METHODS AND RESULTS:
Sixteen compounds were isolated from the ethanol extract of the leaves of Panax notoginseng.They were identified as ginsenoside Rh_2(1),F_2(4),Rg_3(5),Rg_1(7),Rd(8),Re(11),Rb_3(13),Rb_1(14),Rc(15);Gypenoside XIII(2),IX(9),XVII(10);notoginsenoside R_1(12),Fa(16);liquiritigenin(3) and liquiritin apioside(6),respectively.
CONCLUSIONS:
It is noticed that compounds 1,2,3 and 6 are isolated from P.notoginsen for the first time,and compounds 1~8 and 10~12 are isolated from the leaves of this plant for the first time. It is also confirmed that the leaves of notoginseng mainly contain protopanaxdiol saponins along with protopanaxtriol saponins and flavonoids of small quantity.

Gypenoside XIII Dilution Calculator

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Gypenoside XIII Molarity Calculator

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Preparing Stock Solutions of Gypenoside XIII

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3245 mL 6.6225 mL 13.245 mL 26.4901 mL 33.1126 mL
5 mM 0.2649 mL 1.3245 mL 2.649 mL 5.298 mL 6.6225 mL
10 mM 0.1325 mL 0.6623 mL 1.3245 mL 2.649 mL 3.3113 mL
50 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.5298 mL 0.6623 mL
100 mM 0.0132 mL 0.0662 mL 0.1325 mL 0.2649 mL 0.3311 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Description

Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis.

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