Isolappaol A

CAS# 131400-96-9

Isolappaol A

Catalog No. BCN8886----Order now to get a substantial discount!

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Isolappaol A: 5mg $184 In Stock
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Quality Control of Isolappaol A

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Chemical structure

Isolappaol A

3D structure

Chemical Properties of Isolappaol A

Cas No. 131400-96-9 SDF Download SDF
PubChem ID 102232211 Appearance Powder
Formula C30H32O9 M.Wt 536.6
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]methyl]-4-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
SMILES COC1=CC(=CC2=C1OC(C2CO)C3=CC(=C(C=C3)O)OC)CC4C(COC4=O)CC5=CC(=C(C=C5)O)OC
Standard InChIKey YMWGUENGTNUIRA-UHFFFAOYSA-N
Standard InChI InChI=1S/C30H32O9/c1-35-25-11-16(4-6-23(25)32)8-19-15-38-30(34)20(19)9-17-10-21-22(14-31)28(39-29(21)27(12-17)37-3)18-5-7-24(33)26(13-18)36-2/h4-7,10-13,19-20,22,28,31-33H,8-9,14-15H2,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isolappaol A

The roots of Gymnadenia conopsea

Biological Activity of Isolappaol A

DescriptionIsolappaol A can up-regulate the expression of jnk-1, it may promote the Caenorhabditis elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
TargetsJNK
In vitro

Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans.[Reference: WebLink]

Phytochemistry, 01 Jul 2015, 117:340-350.

Arctium lappa is a well-known traditional medicinal plant in China (TCM) and Europe that has been used for thousands of years to treat arthritis, baldness or cancer. The plant produces lignans as secondary metabolites, which have a wide range of bioactivities. Yet, their antiaging potential has not been explored.
METHODS AND RESULTS:
In this study, we isolated six lignans from A. lappa seeds, namely arctigenin, matairesinol, arctiin, Isolappaol A, lappaol A, lappaol C, and lappaol F. The antioxidant and antiaging properties of the isolated lignans were studied using Caenorhabditis elegans as a relevant animal model. All lignans at concentrations of 10 and 100 μM significantly extended the mean life span of C. elegans. The strongest effect was observed with matairesinol, which at a concentration of 100 μM extended the life span of worms by 25%. Additionally, we observed that five lignans are strong free radical-scavengers in vitro and in vivo and all lignans can improve survival of C. elegans under oxidative stress. Furthermore, the lignans can induce the nuclear translocation of the transcription factor DAF-16 and up-regulate its expression, suggesting that a possible underlying mechanism of the observed longevity-promoting activity of lignans depends on DAF-16 mediated signaling pathway.
CONCLUSIONS:
All lignans up-regulated the expression of jnk-1, indicating that lignans may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Our study reports new antiaging activities of lignans, which might be candidates for developing antiaging agents.

Protocol of Isolappaol A

Structure Identification
Microchemical Journal, 2014, 114:238-246.

Identification and quantification of lignans and sesquilignans in the fruits of Cnicus benedictus L.: Quantitative chromatographic and spectroscopic approaches.[Reference: WebLink]


METHODS AND RESULTS:
Identification, quantification and isolation of lignans (Lig-s: arctiin, arctigenin and matairesinol) and sesquilignans (SLig-s: lappaol A, Isolappaol A, lappaol C and isolappaol C), in Cnicus benedictus L. fruit (CBfr) were performed for the first time. Identity of Lig-s and SLig-s was confirmed by gas chromatography–mass spectrometry (GC–MS) and by high performance liquid chromatography–time-of-flight (HPLC–TOF) MS, while their detailed structures were defined by nuclear magnetic resonance (NMR) spectroscopy. As a novelty to the field, fruit part-specific accumulation of Lig-s and SLig-s under germination and their transformation during acidic and enzymatic hydrolyses were followed in a quantitative manner by HPLC–UV. It was shown that during germination, the spontaneous separation of Lig-s and SLig-s occurs: the fruit wall part accumulates SLig-s, while the embryo accumulates the Lig arctiin. It was confirmed that under optimized mild acidic conditions (50 °C, 2 M trifluoroacetic acid, TFA), lappaol C and isolappaol C can be transformed into lappaol A and Isolappaol A, quantitatively. Analytical performance characteristics (reliability and reproducibility), in the HPLC–UV quantifications of Lig-s and SLig-s were defined by the relative standard deviation percentages (RSD%-s) of analyses (averages of RSD%-s ≤ 3.7).
CONCLUSIONS:
Due to our new harmonized analysis system, CBfr proved to be a new and rich source of SLig-s: levels as high as 5.8 mmol/100 g were determined compared to the highest level (0.72 mmol/100 g) reported so far.

Isolappaol A Dilution Calculator

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Isolappaol A Molarity Calculator

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Preparing Stock Solutions of Isolappaol A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8636 mL 9.3179 mL 18.6359 mL 37.2717 mL 46.5896 mL
5 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
10 mM 0.1864 mL 0.9318 mL 1.8636 mL 3.7272 mL 4.659 mL
50 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.3727 mL 0.4659 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isolappaol A

Anti-austeric activity of phenolic constituents of seeds of Arctium lappa.[Pubmed:23738454]

Nat Prod Commun. 2013 Apr;8(4):463-6.

From seeds of Arctium lappa L. (Asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), Isolappaol A (12), lappaol F (14), and lappaol B (15), together with 1:1 mixtures of isolappaol C (7) and lappaol C (8), arctignan E (9) and arctignan D (10), and 12 and lappaol A (13), while 3,3',4'-tri-O-demethylarctigenin (16), 3,3'-di-O-demethyl-4'-dehydroxyarctigenin (17), and 3-O-demethylarctigenin (18) were obtained by anaerobic microbiological metabolism of 1. Then, we evaluated the in vitro preferential cytotoxic activity of these pure compounds and 1:1 mixtures, together with enterodiol (19) and enterolactone (20), against human pancreatic cancer PANC-1 cells in nutrient-deprived medium (NDM). Among them, 1 and 18 showed potent activity, with PC50 values of 1.75 and 4.38 microM, respectively, while 11, 15, and 17 showed mild activity with PC50 values of 31.1, 30.9, and 38.7 microM, respectively. By comparing their structures and PC50 values, the following structural moieties could be concluded to be important for the preferential cytotoxicity of 1: 1) the 3-hydroxy-4-methoxyphenyl group at the 2-position on the gamma-butyrolactone ring, 2) the less polar substituent at the 3-position on the gamma-butyrolactone ring, and 3) the gamma-butyrolactone ring.

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