Oblongine

CAS# 60008-01-7

Oblongine

Catalog No. BCN4103----Order now to get a substantial discount!

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Quality Control of Oblongine

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Chemical structure

Oblongine

3D structure

Chemical Properties of Oblongine

Cas No. 60008-01-7 SDF Download SDF
PubChem ID 173713 Appearance Powder
Formula C19H24NO3 M.Wt 314.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S)-1-[(4-hydroxyphenyl)methyl]-7-methoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium-8-ol
SMILES C[N+]1(CCC2=C(C1CC3=CC=C(C=C3)O)C(=C(C=C2)OC)O)C
Standard InChIKey POJZOQWVMMYVBU-INIZCTEOSA-O
Standard InChI InChI=1S/C19H23NO3/c1-20(2)11-10-14-6-9-17(23-3)19(22)18(14)16(20)12-13-4-7-15(21)8-5-13/h4-9,16H,10-12H2,1-3H3,(H-,21,22)/p+1/t16-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Oblongine

The roots of Stephania tetrandra

Biological Activity of Oblongine

Description1. Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by β-adrenergic receptor stimulation.

Oblongine Dilution Calculator

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Oblongine Molarity Calculator

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Preparing Stock Solutions of Oblongine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1807 mL 15.9033 mL 31.8066 mL 63.6132 mL 79.5165 mL
5 mM 0.6361 mL 3.1807 mL 6.3613 mL 12.7226 mL 15.9033 mL
10 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
50 mM 0.0636 mL 0.3181 mL 0.6361 mL 1.2723 mL 1.5903 mL
100 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Oblongine

Effects of oblongine chloride, an alkaloid from Leontice leontopetalum on guinea-pig isolated smooth muscle and heart.[Pubmed:8482513]

Gen Pharmacol. 1993 Mar;24(2):299-304.

1. The effects of (-)Oblongine chloride, a quaternary alkaloid from Leontice leontopetalum, on guinea-pig isolated ileal longitudinal segments, main pulmonary artery rings, spontaneously-beating atrium and isolated perfused heart were studied. 2. Oblongine chloride (3 x 10(-5)-10(-3) M) caused concentration-dependent relaxation of ileum, an effect which was not blocked by propranolol (10(-6) M) alone or in combination with prazosin (3 x 10(-8) M), or by indomethacin (10(-6) M), but was reduced by desensitization of the preparation by prior exposure to 3 x 10(-5) M ATP and, at high concentrations of Oblongine, by a combination of propranolol and yohimbine (3 x 10(-6) M). 3. Oblongine chloride (10(-5)-3 x 10(-3) M) caused concentration-dependent relaxation of epinephrine-precontracted pulmonary artery. This effect was not affected by propranolol or by indomethacin but was significantly attenuated by pretreatment with 3 x 10(-5) M ATP and potentiated by pretreatment with quinacrine (10(-5) M). 4. Oblongine chloride (10(-5) M-3 x 10(-3) M) caused concentration-dependent increase in the contractility but did not affect the rate of the atrium. Similar effects were obtained with isolated perfused heart except that large concentrations of Oblongine (10(-3), 3 x 10(-3) M) inhibited both contractility and rate of the heart. The inotropic effects of Oblongine on the atrium were not blocked by propranolol or indomethacin but were significantly blocked by quinacrine.(ABSTRACT TRUNCATED AT 250 WORDS)

Description

Oblongine is isolated from the tuber of Stephania cambodica.

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